Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 29

Odds updated as of 11:12 p.m.

The Sunday schedule in MLB includes a matchup between the St. Louis Cardinals and the Cleveland Guardians.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (46-38) vs. Cleveland Guardians (40-41)
• Date: Sunday, June 29, 2025
• Time: 12:05 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Roku

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-126) | CLE: (+108)
• Spread: STL: -1.5 (+138) | CLE: +1.5 (-166)
• Total: 8 -- Over: (-120) | Under: (-102)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 5-6, 3.96 ERA vs Logan Allen (Guardians) - 5-5, 4.25 ERA

The Cardinals will give the ball to Matthew Liberatore (5-6, 3.96 ERA), who is eyeing win No. 6 on the season, and the Guardians will counter with Logan Allen (5-5, 4.25 ERA). Liberatore's team is 6-9-0 against the spread in his starts this season. Liberatore's team has a record of 3-7 this season when he starts and they are the favorite on the moneyline. The Guardians are 5-8-0 against the spread when Allen starts. The Guardians have been the moneyline underdog in 10 of Allen's starts this season, and they went 4-6 in those matchups.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.9%)

Cardinals vs Guardians Moneyline

• The moneyline numbers for Cardinals vs. Guardians reveal St. Louis as the favorite (-126) and Cleveland as the underdog (+108) despite being the home team.

Cardinals vs Guardians Spread

• The Cardinals are at the Guardians and are favored by 1.5 runs on the spread. The Cardinals are +138 to cover the runline, with the Guardians being -166.

Cardinals vs Guardians Over/Under

• Cardinals versus Guardians on June 29 has an over/under of 8 runs, with the odds on the over -120 and the under set at -102.

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Cardinals vs Guardians Betting Trends

• The Cardinals have been chosen as favorites in 36 games this year and have walked away with the win 20 times (55.6%) in those games.
• This year St. Louis has won 15 of 22 games when listed as at least -126 on the moneyline.
• The Cardinals and their opponents have gone over in 44 of their 84 games with a total set by sportsbooks this season.
• The Cardinals have posted a record of 46-38-0 against the spread this season.
• The Guardians have won 21 of the 49 games they were the moneyline underdog this season (42.9%).
• Cleveland has gone 9-20 when it has played as a moneyline underdog with odds of +108 or longer (31%).
• In the 79 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 34 times (34-42-3).
• The Guardians have put together a 38-41-0 record ATS this season.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis OPS (.805) this season. He has a .302 batting average, an on-base percentage of .372, and a slugging percentage of .434.
• He ranks 13th in batting average, 23rd in on-base percentage, and 70th in slugging among qualified hitters in baseball.
• Donovan hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .222 with a home run, three walks and two RBIs.
• Nolan Arenado is batting .245 with 12 doubles, a triple, 10 home runs and 24 walks. He's slugging .393 with an on-base percentage of .306.
• Among qualifying batters, his batting average places him 109th, his on-base percentage 120th, and his slugging percentage 112th.
• Arenado enters this matchup looking to extend his two-game hit streak. In his last five games he is batting .158 with a double, a walk and two RBIs.
• Willson Contreras has collected 73 base hits, an OBP of .341 and a slugging percentage of .427 this season.
• Contreras heads into this matchup with two games in a row with at least one hit. In his last five games he is batting .267 with a double, a home run, four walks and an RBI.
• Lars Nootbaar is batting .227 with a .334 OBP and 35 RBI for St. Louis this season.

Guardians Player Leaders

• Jose Ramirez has accumulated a team-high OBP (.373) and slugging percentage (.505), while pacing the Guardians in hits (92, while batting .312).
• Including all the qualifying players in the big leagues, his batting average ranks eighth, his on-base percentage ranks 22nd, and he is 21st in slugging.
• Steven Kwan is hitting .300 with 18 doubles, a triple, six home runs and 28 walks. He's slugging .426 with an on-base percentage of .363.
• His batting average is 14th among all qualified players, his on-base percentage ranks 28th, and he is 77th in slugging.
• Carlos Santana has six doubles, nine home runs and 36 walks while batting .231.
• Kyle Manzardo is hitting .223 with 11 doubles, two triples, 13 home runs and 25 walks.

Cardinals vs Guardians Head to Head

• 6/28/2025: 9-6 STL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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