Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 15

Odds updated as of 1:11 p.m.

MLB action on Wednesday includes the St. Louis Cardinals facing the Cleveland Guardians.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (9-8) vs. Cleveland Guardians (10-8)
• Date: Wednesday, April 15, 2026
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CleGuardians.TV

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-112) | CLE: (-104)
• Spread: STL: +1.5 (-188) | CLE: -1.5 (+155)
• Total: 9 -- Over: (-115) | Under: (-105)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Dustin May (Cardinals) - 1-2, 9.45 ERA vs Slade Cecconi (Guardians) - 0-2, 5.74 ERA

This contest's pitching matchup is set, as the Cardinals will send Dustin May (1-2) to the mound, while Slade Cecconi (0-2) will take the ball for the Guardians. May and his team have a record of 1-2-0 against the spread when he starts. This will be May's first game as the moneyline favorite this season. The Guardians have a 1-2-0 record against the spread in Cecconi's starts. The Guardians were the moneyline underdog for three Cecconi starts this season -- they lost every game.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.7%)

Cardinals vs Guardians Moneyline

• Cleveland is the underdog, -104 on the moneyline, while St. Louis is a -112 favorite at home.

Cardinals vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Cardinals. The Guardians are +155 to cover, while the Cardinals are -188 to cover as a 1.5-run underdog on the runline.

Cardinals vs Guardians Over/Under

• Cardinals versus Guardians, on April 15, has an over/under of 9, with the over being -115 and the under -105.

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Cardinals vs Guardians Betting Trends

• The Cardinals have split the two match ups they've played as odds-on favorites this season.
• St. Louis has been listed as a favorite of -112 or more on two occasions this season and split those games.
• Contests with the Cardinals have gone over the total set by bookmakers in 10 of 17 chances this season.
• The Cardinals are 8-9-0 against the spread in their 17 games that had a posted line this season.
• The Guardians are 8-6 in games they were the underdog on the moneyline (winning 57.1% of those games).
• Cleveland has an 8-6 record (winning 57.1% of its games) when playing as a moneyline underdog of -104 or longer.
• In the 18 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total nine times (9-9-0).
• The Guardians have covered 61.1% of their games this season, going 11-7-0 ATS.

Cardinals Player Leaders

• Jordan Walker has 21 hits and an OBP of .386 to go with a slugging percentage of .734. All three of those stats rank first among St. Louis hitters this season. He has a .328 batting average, as well.
• Among qualified hitters in baseball, his batting average ranks 13th, his on-base percentage ranks 32nd, and he is second in slugging.
• Walker has recorded at least one hit in 10 straight games. During his last 10 games he is batting .390 with seven home runs, three walks and 12 RBIs.
• Alec Burleson has three doubles, two home runs and 11 walks. He's batting .270 and slugging .413 with an on-base percentage of .373.
• Among qualifiers, he ranks 64th in batting average, 43rd in on-base percentage and 79th in slugging percentage.
• Burleson has picked up a hit in three games in a row. In his last five games he is hitting .263 with a double, a home run, a walk and two RBIs.
• JJ Wetherholt has collected 15 base hits, an OBP of .338 and a slugging percentage of .385 this season.
• Wetherholt brings a two-game hitting streak into this game. In his last five games he is batting .200 with two home runs, two walks and three RBIs.
• Ivan Herrera is batting .200 with a .372 OBP and seven RBI for St. Louis this season.
• Herrera has hit safely in three straight games. During his last five outings he is hitting .211 with a home run, three walks and an RBI.

Guardians Player Leaders

• Jose Ramirez is batting .217 with four doubles, three home runs and 10 walks. He's slugging .406 with an on-base percentage of .316.
• Including all the qualified hitters in the big leagues, he ranks 118th in batting average, 110th in on-base percentage and 85th in slugging percentage.
• Ramirez hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .350 with a double, two home runs, four walks and two RBIs.
• Chase DeLauter's 15 hits pace his team. He has a batting average of .273 while slugging .618 with an on-base percentage of .349.
• He ranks 58th in batting average, 68th in on-base percentage and eighth in slugging percentage in the big leagues.
• Angel Martinez has a .375 on-base percentage and a .510 slugging percentage, both team-best numbers for the Guardians.
• Steven Kwan is slugging .313 to pace his team.

Cardinals vs Guardians Head to Head

• 4/14/2026: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/13/2026: 9-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/29/2025: 7-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/28/2025: 9-6 STL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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