BYU vs Colorado Prediction, Odds, Picks, Best Bets for Week 5 2025

The BYU Cougars versus the Colorado Buffaloes is on the college football schedule for Saturday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

BYU vs Colorado Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BYU: (-235) | Colorado: (+190)
• Spread: BYU: -6.5 (-110) | Colorado: +6.5 (-110)
• Total: 49.5 -- Over: (-110) | Under: (-110)

BYU vs Colorado Betting Trends

• BYU hasn't lost a game against the spread this year.
• BYU is unbeaten ATS (3-0) as a 6.5-point favorite or greater this year.
• One of BYU's three games this season has hit the over.
• Colorado owns two wins against the spread this season.
• Colorado has played two games (out of four) which finished over the total this year.

BYU vs Colorado Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cougars win (66.3%)

BYU vs Colorado Point Spread

BYU is a 6.5-point favorite against Colorado. BYU is -110 to cover the spread, and Colorado is -110.

BYU vs Colorado Over/Under

The BYU-Colorado game on Sept. 27 has been given an over/under of 49.5 points. The over is -110 and the under is -110.

BYU vs Colorado Moneyline

Looking at the moneyline for Colorado-BYU, Colorado is the underdog at +190, and BYU is -235.

BYU vs. Colorado Points Insights

BYU vs. Colorado Game Info

• Game day: Saturday, September 27, 2025
• Game time: 10:15 p.m. ET
• TV channel: ESPN
• Location: Boulder, Colorado
• Stadium: Folsom Field

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Check out even more in-depth BYU vs. Colorado analysis on FanDuel Research.