Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 12:12 a.m.

The MLB's Wednesday schedule includes the Cleveland Guardians taking on the Chicago White Sox.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs White Sox Game Info

• Cleveland Guardians (77-75) vs. Chicago White Sox (77-74)
• Date: Wednesday, September 16, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: ESPN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-172) | CHW: (+144)
• Spread: CLE: -1.5 (+128) | CHW: +1.5 (-154)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 11-9, 2.51 ERA vs TBA (White Sox)

Parker Messick (11-9) will start for the Guardians in this matchup. The White Sox, however, have yet to list a starting pitcher. Messick's team is 15-14-0 against the spread in his starts this season. Messick's team has been victorious in 47.8% of the games he's started as the moneyline favorite with a record of 11-12.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.1%)

Guardians vs White Sox Moneyline

• The moneyline numbers for Guardians vs. White Sox reveal Cleveland as the favorite (-172) and Chicago as the underdog (+144) on the road.

Guardians vs White Sox Spread

• The White Sox are at the Guardians, and are +1.5 on the runline. The White Sox are +128 to cover the spread, and the Guardians are -154.

Guardians vs White Sox Over/Under

• Guardians versus White Sox, on Sept. 16, has an over/under of 7.5, with the over being -122 and the under +100.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have come away with 44 wins in the 86 contests they have been listed as the favorites in this season.
• This year Cleveland has won six of 10 games when listed as at least -172 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 71 of their 144 opportunities.
• In 144 games with a line this season, the Guardians have a mark of 67-77-0 against the spread.
• The White Sox are 50-54 in games they were the underdog on the moneyline (winning 48.1% of those games).
• Chicago has a 5-10 record (winning only 33.3% of its games) when playing as a moneyline underdog of +144 or longer.
• In the 148 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 82 times (82-65-1).
• The White Sox have covered 56.1% of their games this season, going 83-65-0 ATS.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (134) this season while batting .289 with 45 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .453.
• He ranks 12th in batting average, 26th in on-base percentage, and 46th in slugging among qualifying batters in baseball.
• Steven Kwan is slashing .279/.376/.346 this season and leads the Guardians with an OPS of .722.
• Among qualified batters, he ranks 25th in batting average, 10th in on-base percentage and 133rd in slugging percentage.
• Kwan enters this game looking to extend his nine-game hit streak. During his last 10 outings he is batting .350 with four doubles, a home run, four walks and three RBIs.
• Jose Ramirez has collected 99 base hits, an OBP of .317 and a slugging percentage of .359 this season.
• Brayan Rocchio is batting .249 with a .309 OBP and 67 RBI for Cleveland this season.
• Rocchio brings a three-game hitting streak into this matchup. In his last five games he is batting .313 with two doubles, two walks and five RBIs.

White Sox Player Leaders

• Miguel Vargas has 138 hits, a team-best for the White Sox. He's batting .249 and slugging .475 with an on-base percentage of .358.
• Including all the qualifying hitters in the majors, he ranks 82nd in batting average, 34th in on-base percentage and 28th in slugging percentage.
• Vargas hopes to build on a five-game hitting streak in this matchup. During his last five outings he is batting .286 with a home run, two walks and five RBIs.
• Chase Meidroth paces his team with a .399 slugging percentage. He has a batting average of .268 with an on-base percentage of .344.
• His batting average ranks 49th among all qualified players, his on-base percentage is 50th, and he is 93rd in slugging.
• Sam Antonacci a has .367 on-base percentage to pace the White Sox.
• Tristan Peters is hitting .275 with 31 doubles, four triples, 12 home runs and 36 walks.

Guardians vs White Sox Head to Head

• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)

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