Brandon Aiyuk Fantasy Football Week 6: Stats and Projections vs. Buccaneers

Brandon Aiyuk and the San Francisco 49ers will face the Tampa Bay Buccaneers -- whose passing defense was ranked 29th in the NFL last year (243.9 yards allowed per game) -- in Week 6, on Sunday at 4:25 p.m. ET.

Is Aiyuk a daily fantasy option for you this week, as he faces the Buccaneers? More stats and information can be found in this article, so take a look.

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Brandon Aiyuk Week 6 Fantasy Football Projection

• Matchup: San Francisco 49ers at Tampa Bay Buccaneers
• Game Date: October 12, 2025
• Game Time: 4:25 p.m.
• Projected Fantasy Points: 10.6
• PPR Projected Fantasy Points: 12.9
• Projected Receiving Yards: 82.60
• Projected Receiving TDs: 0.40

Projections provided by numberFire

Aiyuk 2024 Fantasy Performance

• Aiyuk was 99th at his position, and 294th overall, with 37.4 fantasy points (5.3 per game) last year.
• In his best game last year, Aiyuk picked up 14.7 fantasy points -- via eight receptions, 147 yards. That was in Week 5 versus the Arizona Cardinals.
• In his second-best performance last year, Aiyuk picked up 4.8 fantasy points -- via two receptions, 48 yards -- in Week 4 against the New England Patriots.
• Aiyuk accumulated 2.3 fantasy points -- two receptions, 23 yards, on six targets -- in his worst game of the year, Week 7 versus the Kansas City Chiefs.
• Aiyuk accumulated 2.8 fantasy points -- two receptions, 28 yards, on five targets -- in his second-worst game of the year (Week 1 versus the New York Jets).

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Buccaneers Defensive Performance

• Last season, Tampa Bay allowed just three quarterbacks to register over 300 passing yards in a game.
• Last season, the Buccaneers allowed 12 QBs to throw at least one TD pass in a game.
• In the passing game, Tampa Bay allowed seven players to throw at least two touchdowns in a game last year.
• Last season, the Buccaneers allowed four players to throw for at least three TDs in a game.
• Tampa Bay let seven players amass over 100 receiving yards in a game last season.
• In terms of pass D, the Buccaneers gave up a touchdown reception to 22 players last season.
• Looking at pass defense, Tampa Bay allowed five players to catch at least two touchdown passes against it last year.
• Looking at run D, the Buccaneers allowed more than 100 yards on the ground to just two players last season.
• In terms of run defense, Tampa Bay allowed at least one rushing touchdown to 12 players last season.
• The Buccaneers allowed at least two rushing TDs on the ground to just one player last season.

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