Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 15

NFL action on Sunday includes the Buffalo Bills taking on the New England Patriots.
Before you place your bet on this matchup at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.
Bills vs Patriots Prediction & Pick
All NFL win probability predictions and picks are according to numberFire.
Prediction: Patriots win (52.3%)
Bills vs Patriots Point Spread
The Bills are 1.5-point favorites against the Patriots. The Bills are -105 to cover the spread, while the Patriots are -115 to cover as a 1.5-point underdog.
Bills vs Patriots Over/Under
The Bills-Patriots matchup on Dec. 14 has been given an over/under of 49.5 points. The over is -110 and the under is -110.
Bills vs Patriots Moneyline
The moneyline numbers for Bills vs. Patriots reveal Buffalo as the favorite (-118) and New England as the underdog (+100) despite being the home team.
Bills vs Patriots Betting Trends
- Buffalo is 6-7-0 against the spread this year.
- The Bills have an ATS record of 4-7 as 1.5-point favorites or greater.
- The Bills have played 13 games this season and six of them have gone over the total.
- The Patriots' record against the spread is 9-4-0.
- Against the spread as 1.5-point underdogs or greater, New England is 3-1.
- The Patriots have seen seven of their 13 games go over the point total.
Check out even more in-depth Bills vs. Patriots analysis on FanDuel Research.
Bills vs Patriots Odds & Spread
- All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
- Moneyline: BUF: (-118) | NE: (+100)
- Spread: BUF: -1.5 (-105) | NE: +1.5 (-115)
- Total: 49.5 -- Over: (-110) | Under: (-110)
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