Astros vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 7:12 p.m.

The Thursday schedule in MLB includes a matchup between the Houston Astros and the Kansas City Royals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Royals Game Info

• Houston Astros (76-76) vs. Kansas City Royals (67-85)
• Date: Thursday, September 17, 2026
• Time: 7:15 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: FOX

Astros vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | KC: (+136)
• Spread: HOU: -1.5 (+126) | KC: +1.5 (-152)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Astros vs Royals Probable Starting Pitchers

Probable Pitchers: Miguel Ullola (Astros) - 0-0, 3.38 ERA vs Seth Lugo (Royals) - 7-8, 4.99 ERA

The Astros will give the nod to Miguel Ullola versus the Royals and Seth Lugo (7-8). Ullola and his team failed to cover the spread in his only opportunity this season as a starter. This will be Ullola's first game as the moneyline favorite this season. When Lugo starts, the Royals are 17-13-0 against the spread. The Royals have a 10-11 record in Lugo's 21 starts this season when they were the moneyline underdog.

Astros vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (60.1%)

Astros vs Royals Moneyline

• Kansas City is the underdog, +136 on the moneyline, while Houston is a -162 favorite at home.

Astros vs Royals Spread

• The Astros are hosting the Royals and are favored by 1.5 runs (+126 to cover) on the runline. Kansas City is -152 to cover.

Astros vs Royals Over/Under

• The over/under for the Astros versus Royals game on Sept. 17 has been set at 8.5, with -124 odds on the over and +102 odds on the under.

Bet on Houston Astros vs. Kansas City Royals on FanDuel today!

Astros vs Royals Betting Trends

• The Astros have won in 34, or 52.3%, of the 65 contests they have been named as odds-on favorites in this year.
• Houston has a record of 7-10 when favored by -162 or more this year.
• Contests with the Astros have gone over the total set by bookmakers in 75 of 152 chances this season.
• The Astros are 76-76-0 against the spread in their 152 games with a line set by sportsbooks this season.
• The Royals are 38-56 in games they were the underdog on the moneyline (winning 40.4% of those games).
• In games it has played as a moneyline underdog with odds of +136 or longer, Kansas City has gone 7-15 (31.8%).
• The Royals have had an over/under set by bookmakers 145 times, and have combined with opponents to go over the total in 65 of those games (65-77-3).
• The Royals have a 75-70-0 record against the spread this season (covering 51.7% of the time).

Astros Player Leaders

• Yordan Alvarez has 164 hits and an OBP of .428 to go with a slugging percentage of .594. All three of those stats are best among Houston hitters this season. He has a .310 batting average, as well.
• Among qualified hitters in the majors, he is third in batting average, first in on-base percentage, and first in slugging.
• Alvarez hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .267 with two doubles, a home run, four walks and three RBIs.
• Isaac Paredes is batting .257 with 26 doubles, a triple, 21 home runs and 64 walks. He's slugging .430 with an on-base percentage of .354.
• Among qualifiers, he is 68th in batting average, 38th in on-base percentage and 64th in slugging percentage.
• Christian Walker is batting .222 with a .412 slugging percentage and 80 RBI this year.
• Jeremy Pena is batting .277 with a .329 OBP and 49 RBI for Houston this season.
• Pena heads into this game on a two-game hitting streak. In his last five games he is hitting .412 with a double, two home runs, a walk and two RBIs.

Royals Player Leaders

• Bobby Witt Jr. has put up a .359 on-base percentage and a .444 slugging percentage, both team-high numbers for the Royals. He's batting .278.
• Including all qualified hitters in the majors, he ranks 24th in batting average, 32nd in on-base percentage and 51st in slugging percentage.
• Carter Jensen has 33 doubles, two triples, 24 home runs and 63 walks while batting .232. He's slugging .453 with an on-base percentage of .319.
• Including all qualified players, his batting average puts him 110th, his on-base percentage ranks 87th, and he is 42nd in slugging.
• Jac Caglianone paces the Royals with 134 hits.
• Salvador Perez is batting .229 with 23 doubles, a triple, 19 home runs and 23 walks.

Astros vs Royals Head to Head

• 9/16/2026: 5-2 KC (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/14/2026: 4-0 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/13/2026: 8-7 HOU (Favorite: Royals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2026: 10-8 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/12/2025: 7-5 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/26/2025: 2-0 KC (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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