Astros vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 1

Odds updated as of 10:13 p.m.

The Houston Astros are among the MLB teams busy on Wednesday, versus the Boston Red Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Astros vs Red Sox Game Info

• Houston Astros (3-2) vs. Boston Red Sox (1-3)
• Date: Wednesday, April 1, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NESN

Astros vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | BOS: (+122)
• Spread: HOU: -1.5 (+146) | BOS: +1.5 (-176)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Astros vs Red Sox Probable Starting Pitchers

Probable Pitchers: Mike Burrows (Astros) - 0-1, 7.94 ERA vs Garrett Crochet (Red Sox) - 1-0, 0.00 ERA

The Astros will call on Mike Burrows versus the Red Sox and Garrett Crochet. Burrows and his team failed to cover the spread in his only opportunity this season as a starter. Burrows' team lost his only start as a favorite this season. Crochet has started just one game with a set spread, which the Red Sox covered. The Red Sox have always been the moneyline underdog when Crochet starts this season.

Astros vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (51.3%)

Astros vs Red Sox Moneyline

• The moneyline numbers for Astros vs. Red Sox reveal Houston as the favorite (-144) and Boston as the underdog (+122) on the road.

Astros vs Red Sox Spread

• The Astros are favored by 1.5 runs at home against the Red Sox. The Astros are +146 to cover the spread, while the Red Sox are -176.

Astros vs Red Sox Over/Under

• The over/under for the Astros versus Red Sox contest on April 1 has been set at 7.5, with -114 odds on the over and -106 odds on the under.

Bet on Houston Astros vs. Boston Red Sox on FanDuel today!

Astros vs Red Sox Betting Trends

• The Astros were victorious in 53, or 53.5%, of the 99 contests they were chosen as favorites last season.
• Last season Houston came away with a win 22 times in 38 chances when named as a favorite of at least -144 or shorter on the moneyline.
• The Astros and their opponents hit the over in 72 of their 161 games with a total last season.
• The Red Sox won 26 of the 56 games they were the underdog on the moneyline last season (46.4%).
• Boston went 9-17 when it played as a moneyline underdog with odds of +122 or longer (34.6%).
• The Red Sox combined with their opponents to hit the over on the total 74 times last season for a 74-83-7 record against the over/under.

Astros Player Leaders

• Last season, Jose Altuve finished with a slugging percentage of .442, fueled by 51 extra-base hits.
• Jeremy Pena had 150 hits and an OBP of .363.
• Last season, Yainer Diaz finished with 20 home runs, 70 RBI and a batting average of .256 last season.
• Christian Walker slashed .238/.297/.421 and finished with an OPS of .717.

Red Sox Player Leaders

• Jarren Duran had 41 doubles, 13 triples, 16 home runs and 60 walks while hitting .256 last season.
• Trevor Story had a .433 slugging percentage while batting .263.
• Ceddanne Rafaela had 34 doubles, four triples, 16 home runs and 28 walks while batting .249 last season.
• Caleb Durbin hit .256 with 25 doubles, 11 home runs and 30 walks.

Astros vs Red Sox Head to Head

• 3/30/2026: 8-1 HOU (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/13/2025: 4-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 8/12/2025: 14-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/11/2025: 7-6 HOU (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/3/2025: 6-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/2/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 8/1/2025: 2-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/21/2024: 4-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/20/2024: 6-5 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/19/2024: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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