Astros vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for June 5

Odds updated as of 6:11 p.m.

In MLB action on Thursday, the Houston Astros face the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Astros vs Pirates Game Info

• Houston Astros (33-28) vs. Pittsburgh Pirates (23-39)
• Date: Thursday, June 5, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and SCHN

Astros vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | PIT: (+122)
• Spread: HOU: -1.5 (+114) | PIT: +1.5 (-137)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Astros vs Pirates Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 5-4, 3.12 ERA vs Mitch Keller (Pirates) - 1-7, 3.73 ERA

The probable starters are Framber Valdez (5-4) for the Astros and Mitch Keller (1-7) for the Pirates. Valdez's team is 5-7-0 against the spread this season in his starts. Valdez's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 5-5. The Pirates have a 5-7-0 record against the spread in Keller's starts. The Pirates are 2-7 in Keller's nine starts this season that they were the moneyline underdog.

Astros vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56%)

Astros vs Pirates Moneyline

• Pittsburgh is the underdog, +122 on the moneyline, while Houston is a -144 favorite despite being on the road.

Astros vs Pirates Spread

• The Pirates are +1.5 on the run line against the Astros. The Pirates are -137 to cover, and the Astros are +114.

Astros vs Pirates Over/Under

• Astros versus Pirates on June 5 has an over/under of 7.5 runs, with the odds on the over -106 and the under set at -114.

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Astros vs Pirates Betting Trends

• The Astros have won in 22, or 53.7%, of the 41 contests they have been named as odds-on favorites in this year.
• This season Houston has come away with a win eight times in 13 chances when named as a favorite of at least -144 on the moneyline.
• The Astros and their opponents have hit the over in 24 of their 61 games with a total set by oddsmakers this season.
• The Astros have an against the spread record of 32-29-0 in 61 games with a line this season.
• The Pirates have won 17 of the 43 games they were the underdog on the moneyline this season (39.5%).
• Pittsburgh has a record of 10-19 in games it has played as a moneyline underdog with odds of +122 or longer (34.5%).
• The Pirates have had an over/under set by bookmakers 60 times, and have combined with opponents to go over the total in 23 of those games (23-34-3).
• The Pirates have covered 45% of their games this season, going 27-33-0 against the spread.

Astros Player Leaders

• Jeremy Pena leads Houston with 72 hits and an OBP of .374, plus a team-best slugging percentage of .481. He's batting .312.
• Among the qualifying hitters in the majors, his batting average ranks 11th, his on-base percentage ranks 26th, and he is 41st in slugging.
• Pena hopes to build on a 10-game hitting streak in this matchup. In his last 10 outings he is hitting .410 with two doubles, three home runs, three walks and five RBIs.
• Isaac Paredes is batting .248 with seven doubles, a triple, 12 home runs and 30 walks, while slugging .447 with an on-base percentage of .342.
• His batting average is 103rd among qualified players, his on-base percentage 60th, and his slugging percentage 60th.
• Jose Altuve has collected 61 base hits, an OBP of .312 and a slugging percentage of .407 this season.
• Altuve has recorded at least one base hit in two straight games. During his last five outings he is batting .222 with a walk.
• Jake Meyers has three home runs, 16 RBI and a batting average of .292 this season.
• Meyers heads into this game on a four-game hitting streak. In his last five games he is hitting .278 with two doubles.

Pirates Player Leaders

• Oneil Cruz has totaled 44 hits, a team-best for the Pirates. He's batting .229 and slugging .474 with an on-base percentage of .353.
• Including all the qualified hitters in the big leagues, he is 136th in batting average, 43rd in on-base percentage and 43rd in slugging percentage.
• Bryan Reynolds is slugging .372 to pace his team. He has a batting average of .235 with an on-base percentage of .305.
• He ranks 124th in batting average, 120th in on-base percentage and 125th in slugging percentage in the big leagues.
• Andrew McCutchen has put up an on-base percentage of .354, a team-high for the Pirates.
• Isiah Kiner-Falefa is hitting .304 with nine doubles, a triple, a home run and nine walks.

Astros vs Pirates Head to Head

• 6/4/2025: 3-0 PIT (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/3/2025: 3-0 HOU (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/31/2024: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/30/2024: 6-2 PIT (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 7/29/2024: 5-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/12/2023: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/11/2023: 7-4 PIT (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/10/2023: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)

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