Astros vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for June 4

Odds updated as of 6:11 p.m.

In MLB action on Wednesday, the Houston Astros play the Pittsburgh Pirates.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Pirates Game Info

• Houston Astros (33-27) vs. Pittsburgh Pirates (22-39)
• Date: Wednesday, June 4, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and SCHN

Astros vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-126) | PIT: (+108)
• Spread: HOU: -1.5 (+126) | PIT: +1.5 (-152)
• Total: 9 -- Over: (-105) | Under: (-115)

Astros vs Pirates Probable Starting Pitchers

Probable Pitchers: Ryan Gusto (Astros) - 3-2, 4.62 ERA vs Mike Burrows (Pirates) - 0-1, 8.64 ERA

This contest's pitching matchup is set, as the Astros will send Ryan Gusto (3-2) to the mound, while Mike Burrows (0-1) will answer the bell for the Pirates. Gusto and his team are 3-4-0 ATS this season when he starts. When Gusto starts a game and his team is the favorite on the moneyline, they have a record of 3-4. Burrows has started two games with set spreads, and the Pirates went 1-1-0. The Pirates were the moneyline underdog for two Burrows starts this season -- they split the games.

Astros vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.6%)

Astros vs Pirates Moneyline

• Pittsburgh is the underdog, +108 on the moneyline, while Houston is a -126 favorite despite being on the road.

Astros vs Pirates Spread

• The Pirates are +1.5 on the spread (-152 to cover), and Houston is +126 to cover the runline.

Astros vs Pirates Over/Under

• Astros versus Pirates, on June 4, has an over/under of 9, with the over being -105 and the under -115.

Bet on Houston Astros vs. Pittsburgh Pirates on FanDuel today!

Astros vs Pirates Betting Trends

• The Astros have been favorites in 40 games this season and have come away with the win 22 times (55%) in those contests.
• This season Houston has been victorious 16 times in 27 chances when named as a favorite of at least -126 on the moneyline.
• The Astros and their opponents have hit the over in 24 of their 60 games with a total set by oddsmakers this season.
• The Astros are 32-28-0 against the spread in their 60 games with a line set by sportsbooks this season.
• The Pirates have won 16 of the 42 games they were listed as the moneyline underdog this season (38.1%).
• Pittsburgh has a 12-22 record (winning only 35.3% of its games) when it has played as a moneyline underdog of +108 or longer.
• The Pirates have combined with opponents to go over the total 23 times this season for a 23-33-3 record against the over/under.
• The Pirates have a 26-33-0 record against the spread this season (covering 44.1% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston in OBP (.372), slugging percentage (.476) and total hits (70) this season. He has a .308 batting average.
• Among qualifying hitters in the majors, his batting average ranks 12th, his on-base percentage ranks 31st, and he is 44th in slugging.
• Pena will look for his 10th straight game with a hit in this matchup. In his last 10 games he is hitting .359 with a double, three home runs, three walks and five RBIs.
• Isaac Paredes is batting .252 with seven doubles, a triple, 12 home runs and 30 walks, while slugging .455 with an on-base percentage of .348.
• His batting average is 92nd among qualified players, his on-base percentage 52nd, and his slugging percentage 56th.
• Jose Altuve has collected 60 base hits, an OBP of .309 and a slugging percentage of .408 this season.
• Jake Meyers has three home runs, 16 RBI and a batting average of .293 this season.
• Meyers has safely hit in three games in a row. During his last five outings he is hitting .235 with two doubles and a walk.

Pirates Player Leaders

• Oneil Cruz has accumulated 42 hits, a team-best for the Pirates. He's batting .223 and slugging .468 with an on-base percentage of .351.
• Including all the qualified hitters in the majors, his batting average ranks 141st, his on-base percentage ranks 46th, and he is 48th in slugging.
• Bryan Reynolds' .372 slugging percentage leads his team. He has a batting average of .234 with an on-base percentage of .302.
• He is currently 125th in batting average, 121st in on-base percentage and 127th in slugging percentage among all qualifying hitters.
• Andrew McCutchen has put up an on-base percentage of .361, a team-best for the Pirates.
• Isiah Kiner-Falefa has nine doubles, a triple, a home run and nine walks while hitting .310.

Astros vs Pirates Head to Head

• 6/3/2025: 3-0 HOU (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/31/2024: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/30/2024: 6-2 PIT (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 7/29/2024: 5-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/12/2023: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/11/2023: 7-4 PIT (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/10/2023: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)

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