Astros vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 7

Odds updated as of 11:12 a.m.

The MLB's Saturday slate includes the Houston Astros taking on the Cleveland Guardians.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Guardians Game Info

• Houston Astros (35-28) vs. Cleveland Guardians (33-29)
• Date: Saturday, June 7, 2025
• Time: 4:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and SCHN

Astros vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | CLE: (-102)
• Spread: HOU: -1.5 (+146) | CLE: +1.5 (-176)
• Total: 7 -- Over: (-122) | Under: (-100)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 8-3, 1.83 ERA vs Gavin Williams (Guardians) - 5-3, 3.79 ERA

The probable pitchers are Hunter Brown (8-3) for the Astros and Gavin Williams (5-3) for the Guardians. Brown's team is 8-4-0 against the spread in his starts this season. Brown's team is 7-3 this season when he starts and they are the moneyline favorite. The Guardians have gone 7-5-0 against the spread when Williams starts. The Guardians have a 4-3 record in Williams' seven starts this season when they were the underdog on the moneyline.

Astros vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (58.8%)

Astros vs Guardians Moneyline

• Houston is the favorite, -116 on the moneyline, while Cleveland is a -102 underdog despite being at home.

Astros vs Guardians Spread

• The Astros are favored by 1.5 runs on the road versus the Guardians. The Astros are +146 to cover the spread, while the Guardians are -176.

Astros vs Guardians Over/Under

• Astros versus Guardians, on June 7, has an over/under of 7, with the over being -122 and the under -100.

Bet on Houston Astros vs. Cleveland Guardians on FanDuel today!

Astros vs Guardians Betting Trends

• The Astros have won in 23, or 54.8%, of the 42 contests they have been named as odds-on favorites in this year.
• Houston has a record of 22-18 in contests when oddsmakers favor them by -116 or more on the moneyline.
• The Astros' games have gone over the total in 24 of their 62 opportunities.
• The Astros have an against the spread record of 33-29-0 in 62 games with a line this season.
• The Guardians have compiled an 18-20 record in games they were the underdog on the moneyline (winning 47.4% of those games).
• Cleveland has a 13-18 record (winning 41.9% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Guardians have played in 60 games with an over/under set, and have combined with opponents to go over the total 27 times (27-31-2).
• The Guardians are 29-31-0 ATS this season.

Astros Player Leaders

• Jeremy Pena leads Houston with 78 hits and an OBP of .382, plus a team-best slugging percentage of .494. He's batting .324.
• Among all qualifying hitters in baseball, he ranks sixth in batting average, 15th in on-base percentage, and 29th in slugging.
• Pena has picked up at least one hit in 12 games in a row. In his last 10 games he is batting .463 with four doubles, three home runs, two walks and six RBIs.
• Isaac Paredes is hitting .254 with seven doubles, a triple, 14 home runs and 34 walks, while slugging .474 with an on-base percentage of .356.
• He ranks 89th in batting average, 39th in on-base percentage and 45th in slugging in MLB.
• Paredes has picked up a hit in two games in a row. During his last five outings he is batting .222 with three home runs, four walks and five RBIs.
• Jose Altuve is batting .267 with a .404 slugging percentage and 24 RBI this year.
• Altuve heads into this game with four games in a row with at least one hit. During his last five outings he is hitting .250 with a walk and two RBIs.
• Jake Meyers has been key for Houston with 55 hits, an OBP of .346 plus a slugging percentage of .396.

Guardians Player Leaders

• Jose Ramirez has an on-base percentage of .382, a slugging percentage of .544, and has 75 hits, all club-bests for the Guardians (while batting .329).
• Including all qualified hitters in the majors, he ranks fourth in batting average, 15th in on-base percentage and 11th in slugging percentage.
• Ramirez takes a six-game hitting streak into this matchup. During his last 10 outings he is batting .425 with four doubles, two home runs, three walks and three RBIs.
• Steven Kwan has 13 doubles, five home runs and 20 walks while batting .306. He's slugging .426 with an on-base percentage of .367.
• Including all qualifying players, he is 13th in batting average, 32nd in on-base percentage and 80th in slugging percentage.
• Carlos Santana has six doubles, seven home runs and 31 walks while batting .256.
• Kyle Manzardo has six doubles, two triples, 11 home runs and 23 walks while hitting .210.

Astros vs Guardians Head to Head

• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/1/2024: 3-2 CLE (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/30/2024: 10-9 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/2/2023: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/1/2023: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/31/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/11/2023: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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