Astros vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 7

Odds updated as of 3:11 p.m.

The Saturday schedule in MLB includes a matchup between the Houston Astros and the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Astros vs Guardians Game Info

• Houston Astros (35-28) vs. Cleveland Guardians (33-29)
• Date: Saturday, June 7, 2025
• Time: 4:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and SCHN

Astros vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-118) | CLE: (-100)
• Spread: HOU: -1.5 (+150) | CLE: +1.5 (-182)
• Total: 7 -- Over: (-105) | Under: (-115)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 8-3, 1.83 ERA vs Gavin Williams (Guardians) - 5-3, 3.79 ERA

The Astros will look to Hunter Brown (8-3) against the Guardians and Gavin Williams (5-3). Brown's team is 8-4-0 against the spread this season in his starts. When Brown starts a game and his team is the favorite on the moneyline, they have a record of 7-3. The Guardians have a 7-5-0 ATS record in Williams' 12 starts with a set spread. The Guardians are 4-3 in Williams' seven starts this season that they were the moneyline underdog.

Astros vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (58.8%)

Astros vs Guardians Moneyline

• Cleveland is a -100 underdog on the moneyline, while Houston is a -118 favorite on the road.

Astros vs Guardians Spread

• The Astros are 1.5-run road favorites on the runline against the Guardians. The Astros are +150 to cover, and the Guardians are -182.

Astros vs Guardians Over/Under

• A total of 7 runs has been set for the Astros-Guardians contest on June 7, with the over available at -105 and the under at -115.

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Astros vs Guardians Betting Trends

• The Astros have been victorious in 23, or 54.8%, of the 42 contests they have been chosen as favorites in this season.
• This season Houston has been victorious 21 times in 37 chances when named as a favorite of at least -118 on the moneyline.
• The Astros and their opponents have gone over the total this season in 24 of their 62 opportunities.
• The Astros are 33-29-0 against the spread in their 62 games with a line set by sportsbooks this season.
• The Guardians have won 47.4% of the games this season they were the moneyline underdog (18-20).
• Cleveland is 12-17 (winning 41.4% of its games) when playing as a moneyline underdog of -100 or longer.
• In the 60 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 27 times (27-31-2).
• The Guardians are 29-31-0 ATS this season.

Astros Player Leaders

• Jeremy Pena leads Houston with 78 hits and an OBP of .382, plus a team-best slugging percentage of .494. He's batting .324.
• Among all qualified hitters in the majors, he is sixth in batting average, 15th in on-base percentage, and 29th in slugging.
• Pena will look for his 13th straight game with a hit in this matchup. During his last 10 outings he is batting .463 with four doubles, three home runs, two walks and six RBIs.
• Isaac Paredes is hitting .254 with seven doubles, a triple, 14 home runs and 34 walks. He's slugging .474 with an on-base percentage of .356.
• He ranks 89th in batting average, 39th in on-base percentage and 45th in slugging in MLB.
• Paredes has picked up at least one hit in two games in a row. In his last five games he is batting .222 with three home runs, four walks and five RBIs.
• Jose Altuve has 64 hits this season and has a slash line of .267/.312/.404.
• Altuve brings a four-game hitting streak into this game. During his last five outings he is batting .250 with a walk and two RBIs.
• Jake Meyers has been key for Houston with 55 hits, an OBP of .346 plus a slugging percentage of .396.

Guardians Player Leaders

• Jose Ramirez has accumulated a team-high OBP (.382) and slugging percentage (.544), while leading the Guardians in hits (75, while batting .329).
• Including all the qualified hitters in the big leagues, his batting average puts him fourth, his on-base percentage is 15th, and he is 11th in slugging.
• Ramirez takes a six-game hitting streak into this matchup. During his last 10 outings he is hitting .425 with four doubles, two home runs, three walks and three RBIs.
• Steven Kwan is hitting .306 with 13 doubles, five home runs and 20 walks. He's slugging .426 with an on-base percentage of .367.
• He is currently 13th in batting average, 32nd in on-base percentage and 80th in slugging percentage among all qualifying hitters.
• Carlos Santana is hitting .256 with six doubles, seven home runs and 31 walks.
• Kyle Manzardo is hitting .210 with six doubles, two triples, 11 home runs and 23 walks.

Astros vs Guardians Head to Head

• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/1/2024: 3-2 CLE (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/30/2024: 10-9 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/2/2023: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/1/2023: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/31/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/11/2023: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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