Astros vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 7:11 p.m.

The Houston Astros will take on the Toronto Blue Jays in MLB action on Tuesday.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs Blue Jays Game Info

• Houston Astros (11-11) vs. Toronto Blue Jays (12-11)
• Date: Tuesday, April 22, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and SN1

Astros vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | TOR: (-102)
• Spread: HOU: +1.5 (-188) | TOR: -1.5 (+155)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Astros vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Ronel Blanco (Astros) - 1-2, 6.48 ERA vs Christopher Michael Bassitt (Blue Jays) - 2-0, 0.77 ERA

This contest's pitching matchup is set, as the Astros will send Ronel Blanco (1-2) to the mound, while Christopher Michael Bassitt (2-0) will answer the bell for the Blue Jays. When Blanco starts, his team is 2-2-0 against the spread this season. Blanco's team is 1-1 this season when he starts and they're favored on the moneyline. In each of Bassitt's four starts that had a set spread, the Blue Jays covered. The Blue Jays have been the moneyline underdog in three of Bassitt's starts this season, and they went 1-2 in those matchups.

Astros vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.5%)

Astros vs Blue Jays Moneyline

• Houston is a -116 favorite on the moneyline, while Toronto is a -102 underdog on the road.

Astros vs Blue Jays Spread

• The Blue Jays are 1.5-run favorites against the spread for this matchup with the Astros. The Blue Jays are +155 to cover, while the Astros are -188 to cover as a 1.5-run underdog on the runline.

Astros vs Blue Jays Over/Under

• The over/under for Astros-Blue Jays on April 22 is 8.5. The over is -118, and the under is -104.

Bet on Houston Astros vs. Toronto Blue Jays on FanDuel today!

Astros vs Blue Jays Betting Trends

• The Astros have been favorites in 14 games this season and have come away with the win seven times (50%) in those contests.
• Houston has a record of 7-6 when favored by -116 or more this year.
• Contests with the Astros have gone over the total set by bookmakers in eight of 22 chances this season.
• The Astros have an against the spread mark of 12-10-0 in 22 games with a line this season.
• The Blue Jays have won 43.8% of the games this season they were the underdog on the moneyline (7-9).
• When it has played as a moneyline underdog with odds of -102 or longer, Toronto has gone 5-8 (38.5%).
• The Blue Jays have had an over/under set by oddsmakers 23 times, and have combined with opponents to go over the total in nine of those games (9-13-1).
• The Blue Jays have collected a 16-7-0 record against the spread this season (covering 69.6% of the time).

Astros Player Leaders

• Jeremy Pena has three doubles, three home runs and eight walks while hitting .228. He has an on-base percentage of .311 and a slugging percentage of .380.
• Among qualified hitters in MLB, his batting average ranks 105th, his on-base percentage ranks 99th, and he is 100th in slugging.
• Pena has recorded a base hit in 12 games in a row. During his last 10 games he is batting .278 with two doubles, a home run, four walks and five RBI.
• Jose Carlos Altuve has 27 hits to go with a slugging percentage of .427, both of which lead Houston hitters this season. He's batting .303 with an on-base percentage of .337.
• Among qualifying batters, his batting average places him 31st, his on-base percentage 76th, and his slugging percentage 73rd.
• Altuve heads into this game looking to extend his two-game hit streak. During his last five outings he is hitting .316 with a double, a walk and two RBI.
• Isaac Paredes leads Houston in OBP (.344) this season, fueled by 19 hits.
• Yordan Ruben Alvarez has been key for Houston with 15 hits, an OBP of .318 plus a slugging percentage of .338.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. is batting .291 with six doubles, a home run and 14 walks. He's slugging .395 with an on-base percentage of .392.
• Including all the qualifying hitters in the big leagues, his batting average is 39th, his on-base percentage is 23rd, and he is 89th in slugging.
• Bo Joseph Bichette leads his team with a .390 slugging percentage. He has a batting average of .310 with an on-base percentage of .352.
• Including all qualified hitters, he ranks 23rd in batting average, 58th in on-base percentage and 92nd in slugging percentage.
• Andres Gimenez has four doubles, three home runs and eight walks while hitting .198.
• George Springer paces his team with 22 hits and a .425 OBP.

Astros vs Blue Jays Head to Head

• 4/21/2025: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/3/2024: 9-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/2/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/1/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/2/2024: 2-1 TOR (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/1/2024: 10-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 6/8/2023: 3-2 TOR (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2023: 3-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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