Western Kentucky vs Southern Miss Prediction, Odds, Picks, Best Bets for New Orleans Bowl 2025

The college football slate on Tuesday includes the Southern Miss Golden Eagles taking on the Western Kentucky Hilltoppers.

We've got you covered, in terms of the most important information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Southern Miss vs Western Kentucky Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Southern Miss: (-124) | Western Kentucky: (+106)
• Spread: Southern Miss: -2.5 (-106) | Western Kentucky: +2.5 (-114)
• Total: 58.5 -- Over: (-115) | Under: (-105)

Southern Miss vs Western Kentucky Betting Trends

• Southern Miss is 5-7-0 against the spread this year.
• Against the spread as 2.5-point or better favorites, Southern Miss is 4-4.
• This year, six of Southern Miss' 12 games have gone over the point total.
• Western Kentucky has covered the spread nine times in 12 games.
• Against the spread as 2.5-point underdogs or more, Western Kentucky is 3-1.
• This year, six of Western Kentucky's 12 games have hit the over.

Southern Miss vs Western Kentucky Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Golden Eagles win (59.2%)

Southern Miss vs Western Kentucky Point Spread

Western Kentucky is an underdog by 2.5 points against Southern Miss. Western Kentucky is -114 to cover the spread, and Southern Miss is -106.

Southern Miss vs Western Kentucky Over/Under

Southern Miss versus Western Kentucky, on Dec. 23, has an over/under of 58.5, with the over being -115 and the under -105.

Southern Miss vs Western Kentucky Moneyline

Western Kentucky is the underdog, +106 on the moneyline, while Southern Miss is a -124 favorite.

Southern Miss vs. Western Kentucky Points Insights

Southern Miss vs. Western Kentucky Game Info

• Game day: Tuesday, December 23, 2025
• Game time: 5:30 p.m. ET
• TV channel: ESPN
• Location: New Orleans, Louisiana
• Stadium: Caesars Superdome

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Check out even more in-depth Southern Miss vs. Western Kentucky analysis on FanDuel Research.