Virginia vs Duke Prediction, Odds, Picks, Best Bets for ACC Championship Game 2025

The college football slate on Saturday includes the Virginia Cavaliers facing the Duke Blue Devils.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Virginia vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Virginia: (-180) | Duke: (+152)
• Spread: Virginia: -3.5 (-114) | Duke: +3.5 (-106)
• Total: 58.5 -- Over: (-110) | Under: (-110)

Virginia vs Duke Betting Trends

• Virginia has covered the spread eight times in 12 games.
• Virginia's ATS record as 3.5-point or bigger favorites is 5-3.
• This year, five of Virginia's 12 games have gone over the point total.
• Duke has six wins in 12 contests against the spread this year.
• Duke has yet to lose ATS (1-0) as a 3.5-point underdog or greater this season.
• Of 12 Duke games so far this year, nine have hit the over.

Virginia vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (66.4%)

Virginia vs Duke Point Spread

Duke is an underdog by 3.5 points versus Virginia. Duke is -106 to cover the spread, and Virginia is -114.

Virginia vs Duke Over/Under

The over/under for Virginia-Duke on Dec. 6 is 58.5. The over is -110, and the under is -110.

Virginia vs Duke Moneyline

Looking at the moneyline for Duke-Virginia, Duke is the underdog at +152, and Virginia is -180.

Virginia vs. Duke Points Insights

Virginia vs. Duke Game Info

• Game day: Saturday, December 6, 2025
• Game time: 8 p.m. ET
• TV channel: ABC
• Location: Charlotte, North Carolina
• Stadium: Bank of America Stadium

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Check out even more in-depth Virginia vs. Duke analysis on FanDuel Research.