Virginia vs American College Basketball Prediction, Odds, Picks, Best Bets for Dec. 22

The American Eagles (7-5) will visit the Virginia Cavaliers (10-1) after losing four road games in a row.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Virginia vs. American Game Info and Odds

• Game day: Monday, December 22, 2025
• Game time: 6 p.m. ET
• TV channel: ACC Network
• Location: Charlottesville, Virginia
• Arena: John Paul Jones Arena

Take a look at the betting insights and trends below before making a bet on Monday's Virginia-American spread (Virginia -27.5) or total (154.5 points).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Virginia vs. American: ATS Betting Stats and Trends

• Virginia has put together a 6-5-0 ATS record so far this year.
• American has compiled a 6-4-0 ATS record so far this year.
• The Cavaliers covered the spread in a lower percentage of their home games than road games last year. They covered seven times in 17 games when playing at home, and they covered five times in 11 games when playing on the road.
• In 2025-26 against the spread, the Eagles have a better winning percentage at home (.667, 4-2-0 record) than on the road (.500, 2-2-0).

Virginia vs. American: Moneyline Betting Stats

• Virginia has been victorious in seven of the eight contests it has been chosen as moneyline favorites in this season.
• This is the best odds of a victory sportsbooks have given the Cavaliers this season with a -33333 moneyline set for this game.
• American has been the moneyline underdog six total times this season. American has gone 1-5 in those games.
• The Eagles have not yet played a game with moneyline odds of +4000 or longer.
• Sportsbooks have implied with the moneyline set for this matchup that Virginia has a 99.7% chance of pulling out a win.

Virginia vs. American Head-to-Head Comparison

• On offense, Virginia was the fifth-worst squad in college basketball (64.8 points per game) last year. On defense, it was 39th (66.8 points allowed per game).
• On the glass, Virginia was worst in the nation in rebounds (26.8 per game) last season. It was 104th in rebounds allowed (30.1 per game).
• At 14.7 assists per game last season, Virginia was 93rd in the nation.
• Last year, Virginia was 25th-best in college basketball in turnovers committed (9.3 per game) but 19th-worst in turnovers forced (9.2).
• On offense, American posted 68.7 points per game (307th-ranked in college basketball) last season. It ceded 67.7 points per contest at the other end of the court (52nd-ranked).
• While American ranked in the bottom 25 in the country in rebounds per game with 28.1 (18th-worst), it ranked 104th in college basketball with 30.1 rebounds allowed per contest.
• American ranked 250th in college basketball with 12.6 assists per contest.
• American was 98th in the country with 10.3 turnovers per game last season. Meanwhile, it ranked 176th with 11.3 forced turnovers per contest.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!