Virginia Tech vs Wake Forest Prediction, Odds, Picks, Best Bets for Week 6 2025

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The college football schedule on Saturday includes the Virginia Tech Hokies taking on the Wake Forest Demon Deacons.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Virginia Tech vs Wake Forest Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Virginia Tech: (-215) | Wake Forest: (+180)
Spread: Virginia Tech: -6.5 (-105) | Wake Forest: +6.5 (-115)
Total: 51.5 -- Over: (-110) | Under: (-110)

Virginia Tech has one win against the spread this year.
Virginia Tech has yet to win ATS (0-1) when playing as at least 6.5-point favorites this season.
Two of five Virginia Tech games have hit the over this year.
Wake Forest has posted two wins against the spread this year.
As a 6.5-point underdog or more, Wake Forest has one win ATS (1-1) this season.
Wake Forest has played two games (out of four) which finished over the total this year.

All college football win probability predictions and picks are according to numberFire.
Prediction: Hokies win (72.9%)

Wake Forest is listed as an underdog by 6.5 points (-115 odds), and Virginia Tech, the favorite, is -105 to cover.

A total of 51.5 points has been set for the Virginia Tech-Wake Forest game on Oct. 4, with the over available at -110 and the under at -110.

Looking at the moneyline for Virginia Tech-Wake Forest, Virginia Tech is the favorite at -215, and Wake Forest is +180.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Virginia Tech	23.6	91	28	105	50.5	5
Wake Forest	26.3	101	20.8	41	54.5	4

Check out even more in-depth Virginia Tech vs. Wake Forest analysis on FanDuel Research.

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