Vanderbilt vs Wake Forest College Basketball Prediction, Odds, Picks, Best Bets for Dec. 21

The Vanderbilt Commodores (11-0) will attempt to extend an 11-game win streak when they visit the Wake Forest Demon Deacons (9-3) on December 21, 2025. The Demon Deacons have won three games in a row.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Vanderbilt vs. Wake Forest Game Info and Odds

• Game day: Sunday, December 21, 2025
• Game time: 1 p.m. ET
• TV channel: The CW Network
• Location: Winston-Salem, North Carolina
• Arena: Lawrence Joel Veterans Memorial Coliseum

Vanderbilt vs. Wake Forest Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Vanderbilt win (56%)

Vanderbilt is a 5.5-point favorite against Wake Forest on Sunday and the total has been set at 162.5 points. Here are a few betting insights and trends if you plan to place a wager on the outing.

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Vanderbilt vs. Wake Forest: ATS Betting Stats and Trends

• Vanderbilt has won six games against the spread this season, while failing to cover five times.
• Wake Forest is 6-6-0 ATS this season.
• Vanderbilt covers the spread when it is a 5.5-point favorite or more 50% of the time. That's less often than Wake Forest covers as an underdog of 5.5 or more (100%).
• The Commodores covered the spread in a higher percentage of their home games than away games last season. They covered 11 times in 17 opportunities at home, and they covered five times in 10 opportunities in away games.
• The Demon Deacons' winning percentage against the spread at home was .375 (6-10-0) last season. Away, it was .500 (6-6-0).

Vanderbilt vs. Wake Forest: Moneyline Betting Stats

• Vanderbilt has yet to lose any of the eight games it has been chosen as the moneyline favorite in this season.
• The Commodores have not lost in seven games this year when favored by -235 or better on the moneyline.
• Wake Forest has gone 1-2 in games it was listed as the moneyline underdog (winning 33.3% of those games).
• The Demon Deacons have played as a moneyline underdog of +190 or longer in just two games this season, which they lost both.
• Vanderbilt has an implied victory probability of 70.1% according to the moneyline set for this matchup.

Vanderbilt vs. Wake Forest Head-to-Head Comparison

• Vanderbilt has a +232 scoring differential, topping opponents by 21.1 points per game. It is putting up 93.7 points per game to rank seventh in college basketball and is giving up 72.6 per outing to rank 166th in college basketball.
• Duke Miles is 127th in the nation with a team-leading 17.1 points per game.
• Wake Forest is outscoring opponents by 13 points per game, with a +156 scoring differential overall. It puts up 85.3 points per game (58th in college basketball) and gives up 72.3 per outing (156th in college basketball).
• Wake Forest's leading scorer, Juke Harris, ranks 33rd in college basketball, scoring 20 points per game.
• The Commodores win the rebound battle by an average of 7.5 boards. They are pulling down 36.1 rebounds per game (69th in college basketball) compared to their opponents' 28.6 per contest.
• Devin averages 7.1 rebounds per game (ranking 154th in college basketball) to lead the Commodores.
• The Demon Deacons pull down 33.1 rebounds per game (189th in college basketball) while allowing 31.7 per outing to opponents. They outrebound opponents by 1.4 boards per game.
• Harris' 6.8 rebounds per game lead the Demon Deacons and rank 184th in the country.
• Vanderbilt ranks eighth in college basketball with 112.5 points scored per 100 possessions, and 74th in college basketball defensively with 87.2 points conceded per 100 possessions.
• The Demon Deacons' 102.3 points per 100 possessions on offense rank 93rd in college basketball, and the 86.7 points they allow per 100 possessions rank 66th in college basketball.

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