Vanderbilt vs Missouri Prediction, Odds, Picks, Best Bets for Week 9 2025

Saturday's slate in college football includes a matchup between the Vanderbilt Commodores and the Missouri Tigers.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Vanderbilt vs Missouri Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Vanderbilt: (-154) | Missouri: (+130)
• Spread: Vanderbilt: -3.5 (100) | Missouri: +3.5 (-122)
• Total: 53.5 -- Over: (-110) | Under: (-110)

Vanderbilt vs Missouri Betting Trends

• Vanderbilt is 5-2-0 against the spread this season.
• Vanderbilt has two wins ATS (2-1) as a 3.5-point or higher favorite in 2025.
• This season, four of Vanderbilt's seven games have hit the over.
• Missouri's record against the spread in 2025 is 5-2-0.
• Missouri has yet to lose ATS (1-0) as a 3.5-point underdog or more this year.
• Of seven Missouri games so far this year, four have hit the over.

Vanderbilt vs Missouri Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Commodores win (61%)

Vanderbilt vs Missouri Point Spread

Missouri is the underdog by 3.5 points against Vanderbilt. Missouri is +100 to cover the spread, and Vanderbilt is -122.

Vanderbilt vs Missouri Over/Under

A combined point total of 53.5 has been set for Vanderbilt-Missouri on Oct. 25, with the over at -110 and the under at -110.

Vanderbilt vs Missouri Moneyline

Vanderbilt is the favorite, -154 on the moneyline, while Missouri is a +130 underdog.

Vanderbilt vs. Missouri Points Insights

Vanderbilt vs. Missouri Game Info

• Game day: Saturday, October 25, 2025
• Game time: 3:30 p.m. ET
• TV channel: ESPN
• Location: Nashville, Tennessee
• Stadium: FirstBank Stadium

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Check out even more in-depth Vanderbilt vs. Missouri analysis on FanDuel Research.