USC vs Michigan Prediction, Odds, Picks, Best Bets for Week 7 2025

The USC Trojans will take on the Michigan Wolverines in college football action on Saturday.

We've got you covered, in terms of the vital info about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

USC vs Michigan Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-144) | Michigan: (+122)
• Spread: USC: -2.5 (-118) | Michigan: +2.5 (-104)
• Total: 56.5 -- Over: (-105) | Under: (-115)

USC vs Michigan Betting Trends

• USC has won twice against the spread this season.
• As at least a 2.5-point favorite, USC has two wins ATS (2-3).
• This season, four of USC's five games have gone over the point total.
• Michigan owns two wins against the spread this season.
• Michigan has no wins ATS (0-1) as a 2.5-point underdog or more this season.
• There have been three Michigan games (out of five) that went over the total this season.

USC vs Michigan Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Wolverines win (50.6%)

USC vs Michigan Point Spread

Michigan is a 2.5-point underdog against USC. Michigan is -104 to cover the spread, and USC is -118.

USC vs Michigan Over/Under

A combined point total of 56.5 has been set for USC-Michigan on Oct. 11, with the over at -105 and the under at -115.

USC vs Michigan Moneyline

USC is a -144 favorite on the moneyline, while Michigan is a +122 underdog.

USC vs. Michigan Points Insights

USC vs. Michigan Game Info

• Game day: Saturday, October 11, 2025
• Game time: 7:30 p.m. ET
• TV channel: NBC
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Michigan analysis on FanDuel Research.