UConn vs DePaul College Basketball Prediction, Odds, Picks, Best Bets for Dec. 21

The UConn Huskies (11-1, 1-0 Big East) will look to continue a seven-game win streak when they visit the DePaul Blue Demons (8-4, 0-1 Big East) on December 21, 2025 at Wintrust Arena.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

UConn vs. DePaul Game Info and Odds

• Game day: Sunday, December 21, 2025
• Game time: 4:30 p.m. ET
• TV channel: Fox Sports 1
• Location: Chicago, Illinois
• Arena: Wintrust Arena

UConn vs. DePaul Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: UConn win (79.2%)

Before you bet on Sunday's UConn-DePaul spread (UConn -12.5) or over/under (134.5 points), check out the betting trends and insights below.

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UConn vs. DePaul: ATS Betting Stats and Trends

• UConn is 4-8-0 ATS this season.
• DePaul has put together a 7-5-0 ATS record so far this season.
• UConn covers the spread when it is a 12.5-point favorite or more 28.6% of the time. That's less often than DePaul covers as an underdog of 12.5 or more (100%).
• The Huskies covered the spread in a lower percentage of their home games than road games last season. They covered eight times in 16 games at home, and they covered six times in 11 games on the road.
• The Blue Demons' winning percentage against the spread at home last season was .474 (9-10-0). Away, it was .417 (5-7-0).

UConn vs. DePaul: Moneyline Betting Stats

• UConn has come away with six wins in the seven contests it has been listed as the moneyline favorite in this season.
• The Huskies have been listed as a favorite of -1053 or more on two occasions this season and won both games.
• DePaul has been the underdog on the moneyline four total times this season. DePaul has gone 1-3 in those games.
• The Blue Demons have played as a moneyline underdog of +640 or longer in only one game this season, which they lost.
• UConn has an implied victory probability of 91.3% according to the moneyline set by oddsmakers for this matchup.

UConn vs. DePaul Head-to-Head Comparison

• UConn has a +208 scoring differential, topping opponents by 17.3 points per game. It is putting up 79 points per game to rank 145th in college basketball and is giving up 61.7 per outing to rank sixth in college basketball.
• Solomon Ball paces UConn, recording 15.4 points per game (251st in college basketball).
• DePaul puts up 76.4 points per game (210th in college basketball) while allowing 68.8 per contest (85th in college basketball). It has a +92 scoring differential and outscores opponents by 7.6 points per game.
• CJ Gunn is ranked 353rd in the country with a team-high 14.3 points per game.
• The Huskies win the rebound battle by 5.8 boards on average. They collect 33.5 rebounds per game, which ranks 168th in college basketball, while their opponents grab 27.7 per outing.
• Alex Karaban tops the team with 5.3 rebounds per game (501st in college basketball action).
• The 31.1 rebounds per game the Blue Demons accumulate rank 276th in the country. Their opponents collect 30.8.
• N.J. Benson paces the team with 6.6 rebounds per game (216th in college basketball).
• UConn ranks 64th in college basketball by averaging 104.8 points per 100 possessions on offense, and defensively is 21st in college basketball, allowing 81.8 points per 100 possessions.
• The Blue Demons rank 174th in college basketball averaging 97.7 points per 100 possessions on offense, and defensively are 96th, allowing 87.9 points per 100 possessions.

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