Twins vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 9:11 p.m.

Monday's slate in the MLB includes a matchup between the Minnesota Twins and the San Francisco Giants.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Twins vs Giants Game Info

• Minnesota Twins (73-83) vs. San Francisco Giants (64-92)
• Date: Monday, September 21, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Twins.TV

Twins vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-126) | SF: (+108)
• Spread: MIN: -1.5 (+134) | SF: +1.5 (-162)
• Total: 8.5 -- Over: (+104) | Under: (-128)

Twins vs Giants Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 9-10, 4.74 ERA vs Blade Tidwell (Giants) - 1-2, 4.56 ERA

The Twins will look to Zebby Matthews (9-10) versus the Giants and Blade Tidwell (1-2). Matthews and his team have a record of 13-8-0 against the spread when he starts. When Matthews starts a game and his team is the favorite on the moneyline, they have a record of 4-4. The Giants have a 4-4-0 record against the spread in Tidwell's starts. The Giants are 2-5 in Tidwell's seven starts this season that they were the underdog on the moneyline.

Twins vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.8%)

Twins vs Giants Moneyline

• Looking at the moneyline for Giants-Twins, San Francisco is the underdog at +108, and Minnesota is -126 playing on the road.

Twins vs Giants Spread

• The Twins are at the Giants and are favored by 1.5 runs on the spread. The Twins are +134 to cover the runline, with the Giants being -162.

Twins vs Giants Over/Under

• The Twins-Giants contest on Sept. 21 has been given an over/under of 8.5 runs. The over is set at +104 and the under at -128.

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Twins vs Giants Betting Trends

• The Twins have won in 30, or 53.6%, of the 56 contests they have been named as odds-on favorites in this year.
• This season Minnesota has been victorious 12 times in 26 chances when named as a favorite of at least -126 on the moneyline.
• Contests with the Twins have gone over the total set by oddsmakers in 86 of 152 chances this season.
• The Twins are 81-71-0 against the spread in their 152 games that had a posted line this season.
• The Giants have won 36.4% of the games this season they were the underdog on the moneyline (39-68).
• When playing as a moneyline underdog with odds of +108 or longer, San Francisco has gone 32-44 (42.1%).
• The Giants have played in 153 games with an over/under set, and have combined with opponents to go over the total 76 times (76-67-10).
• The Giants have put together a 73-80-0 record against the spread this season.

Twins Player Leaders

• Brooks Lee leads Minnesota in slugging percentage (.430) thanks to 50 extra-base hits. He has a .253 batting average and an on-base percentage of .301.
• Among all qualified hitters in MLB, his batting average ranks 74th, his on-base percentage ranks 116th, and he is 64th in slugging.
• Lee has picked up at least one hit in five straight games. In his last five games he is hitting .474 with a double, a walk and two RBIs.
• Josh Bell has an OPS of .741, fueled by an OBP of .320 and a team-best slugging percentage of .421 this season. He's batting .258.
• Among qualified hitters, he is 68th in batting average, 88th in on-base percentage and 73rd in slugging percentage.
• Bell heads into this matchup looking to extend his five-game hit streak. During his last five outings he is batting .364 with a walk and four RBIs.
• Luke Keaschall leads Minnesota with an OBP of .370 this season while batting .278 with 56 walks and 76 runs scored.
• Keaschall has recorded a hit in five straight games. In his last five games he is hitting .409 with a double and two RBIs.
• Kody Clemens leads Minnesota in total hits (120) this season while batting .236 with 55 extra-base hits.

Giants Player Leaders

• Jung Hoo Lee has a .404 slugging percentage, which paces the Giants. He's batting .276 with an on-base percentage of .320.
• Including all qualified hitters, he is 32nd in batting average, while his on-base percentage ranks 88th and he is 85th in slugging.
• Jung Hoo Lee brings a three-game hitting streak into this game. During his last five outings he is batting .263 with two doubles, a home run, two walks and two RBIs.
• Bryce Eldridge is batting .269 with 23 doubles, 17 home runs and 59 walks. He's slugging .461 with an on-base percentage of .364.
• Drew Gilbert has 14 doubles, three triples, 10 home runs and 37 walks while batting .231.
• Christian Koss is batting .228 with five doubles, four home runs and nine walks.

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