Cavaliers vs. 76ers Prediction, Odds, Picks, Best Bets for Nov. 6

Cavaliers vs. 76ers Game Info

• Date: Friday, November 6, 2026
• Time: 7:30 p.m. ET
• Venue: Rocket Arena -- Cleveland, Ohio
• Coverage: Amazon Prime Video, NBCS-PH, and PCK-PHI

The Philadelphia 76ers (8-1) are slightly favored (by 2.5 points) to build on a four-game road win streak when they visit the Cleveland Cavaliers (4-4) on Friday, November 6, 2026 at 7:30 p.m. ET. The matchup has an over/under of 230.5.

Cavaliers vs. 76ers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Cavaliers vs. 76ers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Cavaliers win (71.4%)

Cavaliers vs. 76ers Betting Trends

• The 76ers are 6-3-0 against the spread this season.
• So far this season the Cavaliers have two wins against the spread.
• Games involving the 76ers have hit the over twice out of eight chances this season.
• Cavaliers games this year have hit the over on four of eight set point totals (50%).
• Philadelphia has covered the spread in a lower percentage of its home games than away games. It has covered three times in five games at home, and it has covered three times in four games on the road.
• The 76ers have gone over the over/under in a lower percentage of games at home (20%) than road tilts (25%).
• Cleveland has the same winning percentage against the spread (.250) at home (1-3-0 record) and away (1-3-0) this year.
• Both at home (two of four) and on the road (two of four), the Cavaliers' games have gone over (in terms of the over/under) 50% of the time.

76ers Leaders

• Tyrese Maxey averages 28.0 points, 3.8 boards and 5.4 assists.
• Jaylen Brown is averaging 21.8 points, 6.9 boards and 3.9 assists. At the other end, he averages 1.3 steals and 0.5 blocked shots.
• LeBron James is averaging 15.7 points, 7.4 boards and 7.4 assists. At the other end, he averages 1.4 steals and 0.9 blocked shots.
• Joel Embiid averages 19.6 points, 10.0 boards and 4.4 assists, shooting 41.3% from the floor.
• VJ Edgecombe is averaging 12.5 points, 7.0 rebounds and 3.0 assists. Defensively, he averages 1.1 steals and 0.5 blocked shots.

Cavaliers Leaders

• Donovan Mitchell averages 22.5 points, 5.0 boards and 5.5 assists. He is also draining 48.4% of his shots from the field and 41.1% from beyond the arc, with 2.9 triples per contest.
• The Cavaliers get 18.8 points per game from Evan Mobley, plus 8.3 boards and 3.5 assists.
• James Harden averages 16.6 points, 5.3 rebounds and 6.3 assists. He is making 37.9% of his shots from the field and 36.2% from 3-point range, with 2.6 triples per game.
• The Cavaliers get 13.3 points per game from Jarrett Allen, plus 7.8 boards and 1.3 assists.
• Per game, Mario Hezonja gets the Cavaliers 8.6 points, 5.9 boards and 2.0 assists, plus 0.8 steals and 0.1 blocks.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.