Trail Blazers vs. Pistons Prediction, Odds, Picks, Best Bets for Dec. 22

Trail Blazers vs. Pistons Game Info

• Date: Monday, December 22, 2025
• Time: 10 p.m. ET
• Venue: Moda Center -- Portland, Oregon
• Coverage: KUNP and FDSDET

The Portland Trail Blazers (12-16) are 6-point underdogs as they try to extend a three-game win streak when they host the Detroit Pistons (22-6) on Monday, December 22, 2025 at Moda Center. The matchup airs at 10 p.m. ET on KUNP and FDSDET. The point total for the matchup is 234.5.

Trail Blazers vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Trail Blazers vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction:

Trail Blazers vs. Pistons Betting Trends

• The Pistons have put together a record of 16-12-0 against the spread this season.
• The Trail Blazers have 15 wins against the spread in 28 games this season.
• This season, 15 of the Pistons' games have gone over the point total.
• Trail Blazers games this year have hit the over on 18 of 28 set point totals (64.3%).
• Detroit has a better record against the spread at home (9-6-0) than it does in road games (7-6-0).
• The Pistons have eclipsed the total in nine of 15 home games (60%), compared to six of 13 road games (46.2%).
• This season, Portland is 7-4-0 at home against the spread (.636 winning percentage). Away, it is 8-9-0 ATS (.471).
• Looking at the over/under, Trail Blazers games have gone over more often at home (eight of 11, 72.7%) than away (10 of 17, 58.8%).

Pistons Leaders

• Cade Cunningham is averaging 27 points, 6.4 boards and 9.2 assists. At the other end, he averages 1.4 steals and 0.8 blocked shots.
• Jalen Duren's numbers on the season are 18 points, 11 boards and 1.7 assists per game, shooting 62.5% from the field (seventh in NBA).
• Ausar Thompson averages 11.5 points, 5.7 rebounds and 2.8 assists, shooting 52.1% from the field.
• Isaiah Stewart is averaging 10.3 points, 6.2 rebounds and 1.2 assists.
• Duncan Robinson's numbers on the season are 12 points, 2.9 rebounds and 1.9 assists per contest, shooting 43.5% from the field and 39.5% from beyond the arc, with an average of 2.9 made 3-pointers.

Trail Blazers Leaders

• Deni Avdija's numbers on the season are 25.8 points, 7.1 rebounds and 6.4 assists per contest. He is also draining 47.1% of his shots from the floor and 37% from beyond the arc, with an average of 2.4 triples.
• Per game, Jerami Grant gets the Trail Blazers 20 points, 4 boards and 2.7 assists. He also averages 0.7 steals and 0.6 blocks.
• Shaedon Sharpe averages 22 points, 4.5 boards and 2.5 assists. He is making 46% of his shots from the field and 32.6% from 3-point range, with 2 triples per game.
• Toumani Camara's numbers on the season are 12.6 points, 5.3 boards and 2.9 assists per game. He is sinking 41.6% of his shots from the field and 34.2% from 3-point range, with an average of 2.4 treys.
• The Trail Blazers receive 10.3 points per game from Donovan Clingan, plus 10.3 rebounds and 1.8 assists.

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