Trail Blazers vs. Pistons Prediction, Odds, Picks, Best Bets for Dec. 22

Trail Blazers vs. Pistons Game Info

• Date: Monday, December 22, 2025
• Time: 10 p.m. ET
• Venue: Moda Center -- Portland, Oregon
• Coverage: KUNP and FDSDET

The Portland Trail Blazers (12-16) are underdogs (+5.5) as they try to continue a three-game winning streak when they host the Detroit Pistons (22-6) at 10 p.m. ET on Monday, December 22, 2025 at Moda Center. The game airs on KUNP and FDSDET. The over/under is set at 234.5 for the matchup.

Trail Blazers vs. Pistons Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Trail Blazers vs. Pistons Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (65.6%)

Trail Blazers vs. Pistons Betting Trends

• The Pistons have registered a 16-12-0 record against the spread this season.
• In the Trail Blazers' 28 games this year, they have 15 wins against the spread.
• This season, 15 of the Pistons' games have gone over the point total.
• Trail Blazers games this year have eclipsed the over/under 64.3% of the time (18 out of 28 games with a set point total).
• Detroit has a better record against the spread when playing at home (9-6-0) than it does in road games (7-6-0).
• The Pistons have gone over the over/under more often when playing at home, hitting the over in nine of 15 home matchups (60%). In away games, they have hit the over in six of 13 games (46.2%).
• Portland has been better against the spread at home (7-4-0) than on the road (8-9-0) this year.
• Trail Blazers games have finished above the over/under 72.7% of the time at home (eight of 11), and 58.8% of the time on the road (10 of 17).

Pistons Leaders

• Cade Cunningham averages 27 points, 6.4 rebounds and 9.2 assists.
• Jalen Duren is averaging 18 points, 11 boards and 1.7 assists. Defensively, he averages 0.9 steals and 0.9 blocked shots.
• Ausar Thompson is averaging 11.5 points, 2.8 assists and 5.7 rebounds.
• Isaiah Stewart's numbers on the season are 10.3 points, 6.2 rebounds and 1.2 assists per contest, shooting 53.3% from the floor and 39.3% from downtown, with an average of 1 made treys.
• Duncan Robinson's numbers on the season are 12 points, 2.9 boards and 1.9 assists per game, shooting 43.5% from the field and 39.5% from beyond the arc, with an average of 2.9 made 3-pointers.

Trail Blazers Leaders

• Per game, Deni Avdija gets the Trail Blazers 25.8 points, 7.1 boards and 6.4 assists. He also averages 0.7 steals and 0.6 blocks.
• The Trail Blazers are getting 20 points, 4 boards and 2.7 assists per game from Jerami Grant.
• Shaedon Sharpe's numbers on the season are 22 points, 4.5 rebounds and 2.5 assists per game. He is draining 46% of his shots from the field and 32.6% from 3-point range, with an average of 2 treys.
• The Trail Blazers are receiving 12.6 points, 5.3 rebounds and 2.9 assists per game from Toumani Camara.
• Donovan Clingan averages 10.3 points, 10.3 rebounds and 1.8 assists. He is sinking 50.3% of his shots from the floor.

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