Trail Blazers vs. Clippers Prediction, Odds, Picks, Best Bets for Dec. 26

Trail Blazers vs. Clippers Game Info

• Date: Friday, December 26, 2025
• Time: 10 p.m. ET
• Venue: Moda Center -- Portland, Oregon
• Coverage: Amazon Prime Video

The Los Angeles Clippers (8-21) are just 2.5-point favorites as they look to stop a four-game road losing streak when they take on the Portland Trail Blazers (12-18) on Friday, December 26, 2025 at Moda Center. The matchup airs at 10 p.m. ET on Amazon Prime Video. The matchup's over/under is 227.5.

Trail Blazers vs. Clippers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Trail Blazers vs. Clippers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction:

Trail Blazers vs. Clippers Betting Trends

• The Clippers have put together a 10-19-0 record against the spread this season.
• Against the spread, the Trail Blazers are 15-15-0 this year.
• This season, 16 of the Clippers' games have gone over the point total out of 30 chances.
• Trail Blazers games this year have hit the over on 18 of 30 set point totals (60%).
• In home games, Los Angeles has a worse record against the spread (3-10-0) compared to its ATS record on the road (7-9-0).
• The Clippers have exceeded the total less often when playing at home, hitting the over in seven of 13 home matchups (53.8%). In away games, they have hit the over in nine of 16 games (56.2%).
• Portland has been better against the spread at home (7-6-0) than on the road (8-9-0) this year.
• Trail Blazers games have finished above the over/under 61.5% of the time at home (eight of 13), and 58.8% of the time away (10 of 17).

Clippers Leaders

• James Harden's numbers on the season are 26 points, 5.1 boards and 8.1 assists per contest, shooting 43.5% from the floor and 37.4% from downtown, with an average of 3.6 made 3-pointers (fifth in NBA).
• Kawhi Leonard's numbers on the season are 26.1 points, 6.2 rebounds and 3.3 assists per game, shooting 49.2% from the field and 37% from downtown, with an average of 2.3 made treys.
• John Collins is averaging 12.5 points, 0.9 assists and 4.8 boards.
• Kris Dunn is averaging 8.4 points, 2.9 boards and 2.9 assists. At the other end, he averages 1.5 steals and 0.2 blocked shots.
• Nicolas Batum is averaging 4.5 points, 2.7 boards and 0.7 assists.

Trail Blazers Leaders

• Deni Avdija averages 25.5 points, 7.1 rebounds and 6.6 assists. He is also sinking 46.4% of his shots from the field and 36.6% from 3-point range, with 2.3 triples per contest.
• Shaedon Sharpe averages 22.1 points, 4.4 rebounds and 2.4 assists. He is also making 46.2% of his shots from the field and 31.8% from 3-point range, with 1.9 triples per game.
• Donovan Clingan averages 10.4 points, 10.4 boards and 1.7 assists. He is draining 51.2% of his shots from the field.
• The Trail Blazers are receiving 12.3 points, 5.2 rebounds and 2.8 assists per game from Toumani Camara.
• The Trail Blazers get 5.9 points per game from Kris Murray, plus 4 boards and 1 assists.

For more NBA betting insights, check out FanDuel Research's NBA home page.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Watch FanDuel TV's NBA show "Run It Back" with Lou Williams, Michelle Beadle, DeMarcus "Boogie" Cousins and Chandler Parsons weekdays at 10am ET on FanDuel TV, the Run It Back YouTube page, or download the podcast here: fanduel.com/research/tv-and-podcast.