Tigers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:11 p.m.

The Detroit Tigers versus the San Diego Padres is on the MLB schedule for Tuesday.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Padres Game Info

• Detroit Tigers (14-9) vs. San Diego Padres (16-7)
• Date: Tuesday, April 22, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and SDPA

Tigers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-134) | SD: (+114)
• Spread: DET: -1.5 (+164) | SD: +1.5 (-200)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Tigers vs Padres Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 1-1, 2.53 ERA vs Nick Pivetta (Padres) - 3-1, 1.57 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (1-1) to the mound, while Nick Pivetta (3-1) will answer the bell for the Padres. Flaherty and his team are 2-2-0 ATS this season when he starts. Flaherty's team is 1-1 this season when he starts and they're favored on the moneyline. The Padres are 3-1-0 ATS in Pivetta's four starts with a set spread. The Padres were the underdog on the moneyline for one Pivetta start this season -- they lost.

Tigers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (51.5%)

Tigers vs Padres Moneyline

• Detroit is the favorite, -134 on the moneyline, while San Diego is a +114 underdog on the road.

Tigers vs Padres Spread

• The Tigers are hosting the Padres and are favored by 1.5 runs (+164 to cover) on the runline. San Diego is -200 to cover.

Tigers vs Padres Over/Under

• The Tigers-Padres contest on April 22 has been given an over/under of 7.5 runs. The over is set at +102 and the under at -124.

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Tigers vs Padres Betting Trends

• The Tigers have been chosen as favorites in 11 games this year and have walked away with the win eight times (72.7%) in those games.
• This season Detroit has come away with a win seven times in eight chances when named as a favorite of at least -134 on the moneyline.
• The Tigers and their opponents have hit the over in 10 of their 23 games with a total set by oddsmakers this season.
• The Tigers are 14-9-0 against the spread in their 23 games that had a posted line this season.
• The Padres are 5-5 in games they were listed as the moneyline underdog (winning 50% of those games).
• San Diego is 3-4 (winning 42.9% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Padres have had an over/under set by bookmakers 23 times, and have combined with opponents to go over the total in 10 of those games (10-12-1).
• The Padres have a 14-9-0 record against the spread this season.

Tigers Player Leaders

• Spencer Torkelson leads Detroit with 24 hits and a team-best slugging percentage of .619. He's batting .286 with an on-base percentage of .392.
• Among qualifying hitters in baseball, his batting average ranks 44th, his on-base percentage ranks 23rd, and he is eighth in slugging.
• Torkelson hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is hitting .278 with two doubles, four home runs, six walks and 14 RBI.
• Zach McKinstry has 22 hits this season and a team-best OBP of .424. He's batting .314 and slugging .471.
• Among all qualified, he ranks 22nd in batting average, seventh in on-base percentage and 51st in slugging percentage.
• McKinstry has picked up a hit in four straight games. In his last five games he is batting .444 with two doubles, a triple, four walks and four RBI.
• Kerry Carpenter has 23 hits this season and has a slash line of .315/.338/.562.
• Carpenter brings a five-game hitting streak into this game. During his last five outings he is hitting .474 with a double and an RBI.
• Trey Sweeney is batting .209 with a .274 OBP and eight RBI for Detroit this season.

Padres Player Leaders

• Fernando Tatis Jr. has put up a team-best OBP (.424) and slugging percentage (.663), and paces the Padres in hits (30, while batting .349).
• Including all qualifying players in MLB, he is sixth in batting average, seventh in on-base percentage and fourth in slugging percentage.
• Tatis enters this game on a 10-game hitting streak. During his last 10 games he is batting .333 with a triple, six home runs, five walks and 10 RBI.
• Manny Machado is hitting .306 with nine doubles, two home runs and 10 walks. He's slugging .482 with an on-base percentage of .379.
• He is 26th in batting average, 31st in on-base percentage and 44th in slugging percentage in the big leagues.
• Gavin Sheets is batting .344 with four doubles, three home runs and five walks.
• Xander Bogaerts has eight doubles and 11 walks while hitting .269.

Tigers vs Padres Head to Head

• 4/21/2025: 6-4 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/5/2024: 4-3 DET (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 6-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/2/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 7/23/2023: 3-1 DET (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/22/2023: 14-3 SD (Favorite: Padres, Spread: -1.5, Total: 10, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/21/2023: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/27/2022: 4-3 DET (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/26/2022: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 7/25/2022: 12-4 DET (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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