Tigers vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 6:11 p.m.

The Monday slate in MLB includes a matchup between the Detroit Tigers and the San Diego Padres.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Padres Game Info

• Detroit Tigers (13-9) vs. San Diego Padres (16-6)
• Date: Monday, April 21, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: Fox Sports 1, FDSDETX, and SDPA

Tigers vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-142) | SD: (+120)
• Spread: DET: -1.5 (+146) | SD: +1.5 (-178)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Tigers vs Padres Probable Starting Pitchers

Probable Pitchers: Keider Montero (Tigers) - 0-1, 9.00 ERA vs Randy Vasquez (Padres) - 1-1, 1.74 ERA

This contest's pitching matchup is set, as the Tigers will send Keider Montero (0-1) to the mound, while Randy Vasquez (1-1) will get the nod for the Padres. Montero and his team failed to cover the spread in his only opportunity this season as a starter. This will be Montero's first start this season with his team as the moneyline favorite. The Padres have gone 3-1-0 ATS in Vasquez's four starts with a set spread. The Padres have been the underdog on the moneyline in four of Vasquez's starts this season, and they went 2-2 in those matchups.

Tigers vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56.7%)

Tigers vs Padres Moneyline

• The Tigers vs Padres moneyline has Detroit as a -142 favorite, while San Diego is a +120 underdog on the road.

Tigers vs Padres Spread

• The Tigers are 1.5-run home favorites on the runline against the Padres. The Tigers are +146 to cover, and the Padres are -178.

Tigers vs Padres Over/Under

• A total of 8.5 runs has been set for the Tigers-Padres contest on April 21, with the over available at -105 and the under at -115.

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Tigers vs Padres Betting Trends

• The Tigers have been victorious in seven of the 10 contests they have been chosen as favorites in this season.
• Detroit has a record of 6-1 in contests when sportsbooks favor them by -142 or more on the moneyline.
• The Tigers and their opponents have gone over the total this season in nine of their 22 opportunities.
• The Tigers have posted a record of 13-9-0 against the spread this season.
• The Padres have a 5-4 record in games they were the underdog on the moneyline (winning 55.6% of those games).
• San Diego has gone 1-3 when it has played as a moneyline underdog with odds of +120 or longer (25%).
• In the 22 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total nine times (9-12-1).
• The Padres have put together a 14-8-0 record ATS this season (covering 63.6% of the time).

Tigers Player Leaders

• Spencer Torkelson leads Detroit in slugging percentage (.638) and total hits (23) this season. He's batting .288 with an on-base percentage of .392.
• Among qualifying hitters in the majors, he is 42nd in batting average, 24th in on-base percentage, and seventh in slugging.
• Torkelson will look for his sixth straight game with a hit in this matchup. In his last five games he is batting .353 with two doubles, two home runs, five walks and nine RBI.
• Kerry Carpenter leads Detroit in slugging percentage (.562) thanks to eight extra-base hits. He's batting .315 with an on-base percentage of .338.
• Among qualified hitters, his batting average places him 20th, his on-base percentage 72nd, and his slugging percentage 15th.
• Carpenter heads into this game looking to extend his five-game hit streak. In his last five games he is batting .474 with a double and an RBI.
• Zach McKinstry leads Detroit in OBP (.400) this season, fueled by 19 hits.
• McKinstry has logged a hit or more in three games in a row. In his last five games he is hitting .357 with a double, four walks and three RBI.
• Trey Sweeney has been key for Detroit with 14 hits, an OBP of .290 plus a slugging percentage of .333.

Padres Player Leaders

• Fernando Tatis Jr. has racked up an on-base percentage of .436, a slugging percentage of .691, and has 29 hits, all club-highs for the Padres (while batting .358).
• Including all qualified hitters in the majors, his batting average puts him third, his on-base percentage is fifth, and he is third in slugging.
• Tatis heads into this matchup on a nine-game hitting streak. During his last 10 outings he is hitting .333 with a triple, six home runs, six walks and nine RBI.
• Manny Machado is hitting .305 with nine doubles, two home runs and nine walks. He's slugging .488 with an on-base percentage of .374.
• Including all qualified hitters, his batting average puts him 25th, his on-base percentage is 38th, and he is 41st in slugging.
• Xander Bogaerts has eight doubles and 10 walks while hitting .267.
• Gavin Sheets has four doubles, two home runs and five walks while batting .333.

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