Texas Tech vs Houston Prediction, Odds, Picks, Best Bets for Week 6 2025

College football's Saturday slate includes the Texas Tech Red Raiders taking on the Houston Cougars.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Texas Tech vs Houston Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Texas Tech: (-420) | Houston: (+320)
• Spread: Texas Tech: -10.5 (-112) | Houston: +10.5 (-108)
• Total: 51.5 -- Over: (-110) | Under: (-110)

Texas Tech vs Houston Betting Trends

• Texas Tech has four wins in four games against the spread this year.
• Against the spread as 10.5-point or better favorites, Texas Tech is 3-0.
• Two of Texas Tech's four games have hit the over.
• Houston is 3-1-0 against the spread this season.
• Houston has played four games this season, and three of them have gone over the total.

Texas Tech vs Houston Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Red Raiders win (70.7%)

Texas Tech vs Houston Point Spread

Texas Tech is favored by 10.5 points versus Houston. Texas Tech is -112 to cover the spread, while Houston is -108.

Texas Tech vs Houston Over/Under

Texas Tech versus Houston on Oct. 4 has an over/under of 51.5 points, with the over -110 and the under -110.

Texas Tech vs Houston Moneyline

Houston is the underdog, +320 on the moneyline, while Texas Tech is a -420 favorite.

Texas Tech vs. Houston Points Insights

Texas Tech vs. Houston Game Info

• Game day: Saturday, October 4, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Houston, Texas
• Stadium: TDECU Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Texas Tech vs. Houston analysis on FanDuel Research.