TCU vs Colorado Prediction, Odds, Picks, Best Bets for Week 6 2025

The TCU Horned Frogs will face the Colorado Buffaloes in college football action on Saturday.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

TCU vs Colorado Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TCU: (-521) | Colorado: (+400)
• Spread: TCU: -13.5 (-118) | Colorado: +13.5 (-104)
• Total: 57.5 -- Over: (-110) | Under: (-110)

TCU vs Colorado Betting Trends

• TCU has two wins against the spread this year.
• TCU is winless ATS (0-1) as a 13.5-point favorite or greater this season.
• Two of TCU's four games have gone over the point total.
• Colorado has three wins in five contests against the spread this year.
• Colorado has played two games (out of five) which finished over the total this year.

TCU vs Colorado Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Horned Frogs win (59.3%)

TCU vs Colorado Point Spread

Colorado is an underdog by 13.5 points versus TCU. Colorado is -104 to cover the spread, and TCU is -118.

TCU vs Colorado Over/Under

The over/under for the TCU versus Colorado game on Oct. 4 has been set at 57.5, with -110 odds on the over and -110 odds on the under.

TCU vs Colorado Moneyline

The TCU vs Colorado moneyline has TCU as a -521 favorite, while Colorado is a +400 underdog.

TCU vs. Colorado Points Insights

TCU vs. Colorado Game Info

• Game day: Saturday, October 4, 2025
• Game time: 7:30 p.m. ET
• TV channel: FOX
• Location: Fort Worth, Texas
• Stadium: Amon G. Carter Stadium

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Check out even more in-depth TCU vs. Colorado analysis on FanDuel Research.