Syracuse vs North Carolina Prediction, Odds, Picks, Best Bets for Week 10 2025

The Syracuse Orange versus the North Carolina Tar Heels is on the college football schedule for Friday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Syracuse vs North Carolina Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Syracuse: (-126) | North Carolina: (+108)
• Spread: Syracuse: -2.5 (-110) | North Carolina: +2.5 (-110)
• Total: 44.5 -- Over: (-115) | Under: (-105)

Syracuse vs North Carolina Betting Trends

• Syracuse has covered the spread three times in eight games.
• Syracuse owns one win ATS (1-1) as a 2.5-point favorite or greater this year.
• This season, four of Syracuse's eight games have go over the point total.
• Against the spread, North Carolina is 4-3-0 this season.
• North Carolina has two wins ATS (2-3) as a 2.5-point underdog or more this season.
• A pair of North Carolina seven games in 2025 have hit the over.

Syracuse vs North Carolina Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Orange win (58.1%)

Syracuse vs North Carolina Point Spread

North Carolina is a 2.5-point underdog against Syracuse. North Carolina is -110 to cover the spread, and Syracuse is -110.

Syracuse vs North Carolina Over/Under

Syracuse versus North Carolina on Oct. 31 has an over/under of 44.5 points, with the over -115 and the under -105.

Syracuse vs North Carolina Moneyline

Looking at the moneyline for North Carolina-Syracuse, North Carolina is the underdog at +108, and Syracuse is -126.

Syracuse vs. North Carolina Points Insights

Syracuse vs. North Carolina Game Info

• Game day: Friday, October 31, 2025
• Game time: 7:30 p.m. ET
• TV channel: ESPN
• Location: Syracuse, New York
• Stadium: JMA Wireless Dome

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