Spurs vs. Trail Blazers NBA Playoffs Prediction, Odds, Picks, Best Bets for April 21

Spurs vs. Trail Blazers Game Info

• Date: Tuesday, April 21, 2026
• Time: 8 p.m. ET
• Venue: Frost Bank Center -- San Antonio, Texas
• Coverage: NBC/Peacock

The San Antonio Spurs are double-digit 11.5-point favorites for Game 2 of the opening round of the NBA Playoffs against the Portland Trail Blazers at Frost Bank Center on Tuesday, beginning at 8 p.m. ET on NBC/Peacock. The Spurs hold a 1-0 lead in the series. The matchup has an over/under of 220.5 points.

Spurs vs. Trail Blazers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Spurs vs. Trail Blazers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Spurs win (76.4%)

Spurs vs. Trail Blazers Betting Trends

• The Spurs have compiled a 43-34-4 record against the spread this season.
• The Trail Blazers have played 82 games, with 45 wins against the spread.
• Spurs games have finished with a final combined score above the over/under 36 times this season.
• The Trail Blazers have hit the over 51.2% of the time this season (42 of 82 games with a set point total).
• Against the spread, San Antonio has performed worse when playing at home, covering 19 times in 40 home games, and 24 times in 42 road games.
• The Spurs have gone over the total in 18 of 40 home games (45%), compared to 18 of 42 road games (42.9%).
• Portland's winning percentage against the spread at home is .610 (25-16-0). On the road, it is .488 (20-21-0).
• Trail Blazers games have gone above the over/under more often at home (25 times out of 41) than away (17 of 41) this season.

Spurs Leaders

• Victor Wembanyama averages 25 points, 11.5 rebounds and 3.1 assists, shooting 51.2% from the field and 34.9% from downtown, with 1.9 made 3-pointers per contest.
• De'Aaron Fox averages 18.6 points, 3.8 boards and 6.2 assists, shooting 48.6% from the floor and 33.2% from downtown, with 1.8 made 3-pointers per contest.
• Stephon Castle averages 16.6 points, 5.3 boards and 7.4 assists, shooting 47.1% from the floor and 33.2% from beyond the arc, with 1.2 made treys per game.
• Keldon Johnson's numbers on the season are 13.2 points, 5.4 rebounds and 1.4 assists per contest, shooting 51.9% from the field and 36.3% from downtown, with an average of 1.2 made 3-pointers.
• Julian Champagnie is averaging 11.1 points, 5.8 rebounds and 1.5 assists. At the other end, he averages 0.8 steals and 0.5 blocked shots.

Trail Blazers Leaders

• Deni Avdija averages 24.2 points for the Trail Blazers, plus 6.9 rebounds and 6.7 assists.
• The Trail Blazers are receiving 12.1 points, 11.6 rebounds and 2.1 assists per game from Donovan Clingan.
• Per game, Toumani Camara provides the Trail Blazers 13.4 points, 5.1 boards and 2.5 assists, plus 1.1 steals and 0.4 blocks.
• Jrue Holiday averages 16.3 points, 4.6 rebounds and 6.1 assists. He is draining 45.1% of his shots from the field and 37.8% from 3-point range, with 2.6 treys per game.
• The Trail Blazers receive 18.6 points per game from Jerami Grant, plus 3.5 rebounds and 2.1 assists.

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