Southern Miss vs Louisiana Prediction, Odds, Picks, Best Bets for Week 8 2025

College football's Saturday schedule includes the Southern Miss Golden Eagles taking on the Louisiana Ragin' Cajuns.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Southern Miss vs Louisiana Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Southern Miss: (-164) | Louisiana: (+138)
• Spread: Southern Miss: -3.5 (-112) | Louisiana: +3.5 (-108)
• Total: 54.5 -- Over: (-110) | Under: (-110)

Southern Miss vs Louisiana Betting Trends

• Southern Miss is 3-3-0 against the spread this year.
• As at least a 3.5-point favorite, Southern Miss has two wins ATS (2-1).
• There have been four Southern Miss games (of six) that hit the over this year.
• Louisiana has won twice against the spread this season.
• Louisiana has won once ATS (1-1) as a 3.5-point underdog or more this season.
• This year, three of Louisiana's five games have hit the over.

Southern Miss vs Louisiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Ragin' Cajuns win (51.4%)

Southern Miss vs Louisiana Point Spread

Southern Miss is favored by 3.5 points over Louisiana. Southern Miss is -112 to cover the spread, with Louisiana being -108.

Southern Miss vs Louisiana Over/Under

Southern Miss versus Louisiana on Oct. 18 has an over/under of 54.5 points, with the over -110 and the under -110.

Southern Miss vs Louisiana Moneyline

Looking at the moneyline for Louisiana-Southern Miss, Louisiana is the underdog at +138, and Southern Miss is -164.

Southern Miss vs. Louisiana Points Insights

Southern Miss vs. Louisiana Game Info

• Game day: Saturday, October 18, 2025
• Game time: 5 p.m. ET
• TV channel: ESPN+
• Location: Lafayette, Louisiana
• Stadium: Cajun Field at Our Lady of Lourdes Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Southern Miss vs. Louisiana analysis on FanDuel Research.