South Florida vs Old Dominion Prediction, Odds, Picks, Best Bets for Cure Bowl 2025

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On Wednesday in college football, the South Florida Bulls are up against the Old Dominion Monarchs.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

South Florida vs Old Dominion Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: South Florida: (-180) | Old Dominion: (+152)
Spread: South Florida: -3.5 (-115) | Old Dominion: +3.5 (-105)
Total: 52.5 -- Over: (-110) | Under: (-110)

South Florida's record against the spread is 9-3-0.
South Florida's ATS record as 3.5-point or bigger favorites is 6-2.
This year, seven of South Florida's 12 games have hit the over.
Old Dominion has seven wins in 12 contests against the spread this season.
Old Dominion has yet to lose ATS (2-0) as a 3.5-point underdog or greater this season.
Old Dominion has played 12 games this year, and five of them have gone over the total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulls win (64.2%)

Old Dominion is a 3.5-point underdog against South Florida. Old Dominion is -105 to cover the spread, and South Florida is -115.

The over/under for South Florida-Old Dominion on Dec. 17 is 52.5. The over is -110, and the under is -110.

The South Florida vs Old Dominion moneyline has South Florida as a -180 favorite, while Old Dominion is a +152 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
South Florida	43.0	4	23.3	54	61.8	12
Old Dominion	32.7	35	19.3	18	54.8	12

Check out even more in-depth South Florida vs. Old Dominion analysis on FanDuel Research.

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