South Florida vs Charlotte Prediction, Odds, Picks, Best Bets for Week 6 2025

Friday's slate in college football includes a matchup between the South Florida Bulls and the Charlotte 49ers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding today's NCAA football betting odds.

South Florida vs Charlotte Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: South Florida: (-7143) | Charlotte: (+2000)
• Spread: South Florida: -27.5 (-120) | Charlotte: +27.5 (-102)
• Total: 55.5 -- Over: (-115) | Under: (-105)

South Florida vs Charlotte Betting Trends

• South Florida has three wins in four games against the spread this year.
• South Florida is unbeaten ATS (1-0) as a 27.5-point favorite or greater this year.
• Two of four South Florida games have gone over the point total this year.
• Charlotte has one win against the spread this year.
• Two Charlotte games (of four) have hit the over this year.

South Florida vs Charlotte Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulls win (90%)

South Florida vs Charlotte Point Spread

South Florida is a 27.5-point favorite against Charlotte. South Florida is -120 to cover the spread, and Charlotte is -102.

South Florida vs Charlotte Over/Under

A total of 55.5 points has been set for the South Florida-Charlotte matchup on Oct. 3, with the over available at -115 and the under at -105.

South Florida vs Charlotte Moneyline

Looking at the moneyline for Charlotte-South Florida, Charlotte is the underdog at +2000, and South Florida is -7143.

South Florida vs. Charlotte Points Insights

South Florida vs. Charlotte Game Info

• Game day: Friday, October 3, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Tampa, Florida
• Stadium: Raymond James Stadium

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Check out even more in-depth South Florida vs. Charlotte analysis on FanDuel Research.