South Florida vs Charlotte Prediction, Odds, Picks, Best Bets for Week 6 2025

In college football action on Friday, the South Florida Bulls face the Charlotte 49ers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding today's NCAA football betting odds.

South Florida vs Charlotte Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: South Florida: (-4545) | Charlotte: (+1600)
• Spread: South Florida: -27.5 (-110) | Charlotte: +27.5 (-110)
• Total: 54.5 -- Over: (-115) | Under: (-105)

South Florida vs Charlotte Betting Trends

• Against the spread, South Florida is 3-1-0 this season.
• South Florida has yet to lose ATS (1-0) as a 27.5-point favorite or greater this season.
• Two of four South Florida games have hit the over this year.
• Charlotte has one win against the spread this season.
• A pair of Charlotte four games in 2025 have gone over the point total.

South Florida vs Charlotte Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulls win (90%)

South Florida vs Charlotte Point Spread

Charlotte is a 27.5-point underdog against South Florida. Charlotte is -110 to cover the spread, and South Florida is -110.

South Florida vs Charlotte Over/Under

An over/under of 54.5 has been set for South Florida-Charlotte on Oct. 3, with the over being -115 and the under -105.

South Florida vs Charlotte Moneyline

Charlotte is a +1600 underdog on the moneyline, while South Florida is a -4545 favorite.

South Florida vs. Charlotte Points Insights

South Florida vs. Charlotte Game Info

• Game day: Friday, October 3, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN2
• Location: Tampa, Florida
• Stadium: Raymond James Stadium

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Check out even more in-depth South Florida vs. Charlotte analysis on FanDuel Research.