SMU vs Syracuse Prediction, Odds, Picks, Best Bets for Week 6 2025

In college football action on Saturday, the SMU Mustangs take on the Syracuse Orange.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

SMU vs Syracuse Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SMU: (-820) | Syracuse: (+570)
• Spread: SMU: -17.5 (-110) | Syracuse: +17.5 (-110)
• Total: 57.5 -- Over: (-105) | Under: (-115)

SMU vs Syracuse Betting Trends

• SMU is winless against the spread this season.
• SMU has no wins ATS (0-1) as a 17.5-point favorite or greater this season.
• One of three SMU games have gone over the point total this season.
• Syracuse owns two wins against the spread this year.
• There have been three Syracuse games (out of five) that went over the total this year.

SMU vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Mustangs win (81.7%)

SMU vs Syracuse Point Spread

SMU is favored by 17.5 points against Syracuse. SMU is -110 to cover the spread, while Syracuse is -110.

SMU vs Syracuse Over/Under

SMU versus Syracuse on Oct. 4 has an over/under of 57.5 points, with the over -105 and the under -115.

SMU vs Syracuse Moneyline

The SMU vs Syracuse moneyline has SMU as a -820 favorite, while Syracuse is a +570 underdog.

SMU vs. Syracuse Points Insights

SMU vs. Syracuse Game Info

• Game day: Saturday, October 4, 2025
• Game time: 3:30 p.m. ET
• TV channel: ACC Network
• Location: University Park, Texas
• Stadium: Gerald J. Ford Stadium

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Check out even more in-depth SMU vs. Syracuse analysis on FanDuel Research.