SMU vs Louisville Prediction, Picks, College Football Odds & 3 Best Bets Today

College Football Betting Picks in Summary

• Louisville -1.5
• Over 58.5
• Louisville Over 160.5 Rushing Yards

SMU travels to Louisville Saturday afternoon in a genuine coin flip — one of the closest spreads on the entire board, with the road team actually carrying the stronger yardage projection of the two.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

SMU at Louisville (Sat, 3:30 p.m. ET)

Louisville -1.5 (-112)

A near pick'em number in a genuinely even matchup — SMU's own yardage total (423.5) actually sits ahead of Louisville's (420.5), about as close as these projections come.

Over 58.5 (-110)

Two comparably matched offenses combining for a projected 844 total yards points toward a genuine shootout — one of the highest totals on the entire Saturday board.

Louisville Over 160.5 Rushing Yards (-114)

Louisville's rushing attack projects notably heavier than SMU's (160.5 to 117.5), a real sign the Cardinals figure to lean on the ground game as a genuine point of emphasis at home.