Mississippi State vs South Carolina Prediction, Picks, Odds & College Football Best Bets

College Football Betting Picks in Summary

• South Carolina -3.5
• Over 58.5
• South Carolina Over 176.5 Rushing Yards

Mississippi State travels to South Carolina Saturday afternoon in a genuinely competitive matchup — a modest 3.5-point spread with real, comparable yardage projections on both sides.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Mississippi State at South Carolina (Sat, 4:15 p.m. ET)

South Carolina -3.5 (-105)

A modest home favorite in a genuinely close matchup — South Carolina's own yardage total (436.5) sits just 24 yards ahead of Mississippi State's (412.5), a fair reflection of the number without needing a blowout to justify it.

Over 58.5 (-115)

Both offenses carry real, sizable yardage projections — a combined 849 yards between the two team totals — pointing toward a genuine back-and-forth scoring game rather than a defensive grind.

South Carolina Over 176.5 Rushing Yards (-114)

South Carolina's rushing attack projects notably heavier than Mississippi State's (176.5 to 152.5), a real sign the Gamecocks figure to lean on the ground game as a genuine point of emphasis at home.