Senators vs Sabres NHL Prediction, Odds, Picks, Best Bets for Oct. 15

The Ottawa Senators versus the Buffalo Sabres is on the NHL schedule for Wednesday.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital info about today's NHL betting odds.

Senators vs Sabres Game Info

• Ottawa Senators (1-2) vs. Buffalo Sabres (0-3)
• Date: Wednesday, October 15, 2025
• Time: 7 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Senators vs Sabres Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Senators vs Sabres Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Senators win (53.3%)

Senators vs Sabres Puck Line

• The Sabres are underdogs by 1.5 goals. The Sabres are -265 to cover the spread, and the Senators are +210.

Senators vs Sabres Over/Under

• The over/under for the Senators versus Sabres game on Oct. 15 has been set at 5.5, with -138 odds on the over and +112 odds on the under.

Senators vs Sabres Moneyline

• Buffalo is a -104 underdog on the moneyline, while Ottawa is a -115 favorite on the road.

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