Saint Louis vs Loyola Chicago College Basketball Prediction, Odds, Picks, Best Bets for March 4

The Saint Louis Billikens (26-3, 14-2 A-10) will attempt to continue a 13-game home winning streak when they take on the Loyola Chicago Ramblers (7-22, 3-13 A-10) on March 4, 2026 at Chaifetz Arena.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Saint Louis vs. Loyola Chicago Game Info and Odds

• Game day: Wednesday, March 4, 2026
• Game time: 8 p.m. ET
• TV channel: CBS Sports Network
• Location: St. Louis, Missouri
• Arena: Chaifetz Arena

Saint Louis vs. Loyola Chicago Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Saint Louis win (98.6%)

Take a look at the betting trends and insights below before making a wager on Wednesday's Saint Louis-Loyola Chicago spread (Saint Louis -24.5) or total (155.5 points).

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Saint Louis vs. Loyola Chicago: ATS Betting Stats and Trends

• Saint Louis is 17-11-0 ATS this season.
• Loyola Chicago has covered nine times in 29 games with a spread this season.
• The Billikens have covered the spread in a higher percentage of their home games than road games. They have covered 13 times in 17 opportunities when playing at home, and they've covered four times in nine opportunities in away games.
• Against the spread, the Ramblers have an identical winning percentage (.333) at home (5-10-0 record) and on the road (3-6-0).
• Saint Louis' record against the spread in conference games is 10-6-0.
• Loyola Chicago has beaten the spread seven times in 16 A-10 games.

Saint Louis vs. Loyola Chicago: Moneyline Betting Stats

• Saint Louis has been victorious in 23, or 88.5%, of the 26 contests it has been chosen as moneyline favorites in this season.
• The Billikens have been a -10000 moneyline favorite on four occasions this season and won every game.
• Loyola Chicago has been the moneyline underdog 20 total times this season. Loyola Chicago has gone 3-17 in those games.
• The Ramblers have not yet played a game with moneyline odds of +2500 or longer.
• The moneyline set for this matchup implies Saint Louis has a 99% chance of walking away with the win.

Saint Louis vs. Loyola Chicago Head-to-Head Comparison

• Saint Louis is outscoring opponents by 20.5 points per game with a +594 scoring differential overall. It puts up 89.2 points per game (seventh in college basketball) and gives up 68.7 per outing (51st in college basketball).
• Saint Louis' leading scorer, Robbie Avila, is 558th in the nation averaging 13 points per game.
• Loyola Chicago's -291 scoring differential (being outscored by 10 points per game) is a result of putting up 66.8 points per game (347th in college basketball) while allowing 76.8 per contest (258th in college basketball).
• Loyola Chicago's leading scorer, Miles Rubin, ranks 880th in college basketball, averaging 11.1 points per game.
• The Billikens win the rebound battle by 8.8 boards on average. They collect 37.8 rebounds per game, which ranks seventh in college basketball, while their opponents grab 29 per outing.
• Dion Brown is 359th in college basketball action with 5.7 rebounds per game to lead the Billikens.
• The Ramblers grab 30.9 rebounds per game (242nd in college basketball), compared to the 30.4 of their opponents.
• Rubin is 132nd in the nation with 7.2 rebounds per game, leading the Ramblers.
• Saint Louis scores 109.7 points per 100 possessions (fifth in college basketball), while giving up 84.5 points per 100 possessions (ninth in college basketball).
• The Ramblers' 89.5 points per 100 possessions on offense rank 335th in college basketball, and the 102.9 points they concede per 100 possessions rank 342nd in college basketball.

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