Saint Louis vs Duquesne College Basketball Prediction, Odds, Picks, Best Bets for Feb. 28

The Saint Louis Billikens (25-3, 13-2 A-10) aim to build on a 12-game home winning streak when they host the Duquesne Dukes (16-12, 8-7 A-10) on February 28, 2026.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Saint Louis vs. Duquesne Game Info and Odds

• Game day: Saturday, February 28, 2026
• Game time: 8 p.m. ET
• TV channel: ESPN+
• Location: St. Louis, Missouri
• Arena: Chaifetz Arena

Saint Louis vs. Duquesne Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Saint Louis win (92.4%)

Saint Louis is a 14.5-point favorite over Duquesne on Saturday and the total is set at 160.5 points. Keep reading for a few betting trends and insights before you place a wager on the matchup.

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Saint Louis vs. Duquesne: ATS Betting Stats and Trends

• Saint Louis has put together a 16-11-0 record against the spread this season.
• Duquesne has won 12 games against the spread this season, while failing to cover 14 times.
• The Billikens have a better record against the spread when playing at home (12-4-0) than they do in away games (4-5-0).
• The Dukes have performed better against the spread on the road (7-3-0) than at home (5-10-0) this year.
• Saint Louis has covered the spread nine times in 15 conference games.
• Duquesne has eight wins against the spread in 15 A-10 games this year.

Saint Louis vs. Duquesne: Moneyline Betting Stats

• Saint Louis has been victorious in 22, or 88%, of the 25 contests it has been chosen as moneyline favorites in this season.
• The Billikens have not lost in 12 games this year when favored by -1449 or better on the moneyline.
• Duquesne has put together a 4-7 record in games it was the underdog on the moneyline (winning 36.4% of those games).
• The Dukes have not yet played a game with moneyline odds of +810 or longer.
• Oddsmakers have implied with the moneyline set for this matchup that Saint Louis has a 93.5% chance of pulling out a win.

Saint Louis vs. Duquesne Head-to-Head Comparison

• Saint Louis' +579 scoring differential (outscoring opponents by 20.7 points per game) is a result of scoring 89.1 points per game (seventh in college basketball) while giving up 68.4 per contest (47th in college basketball).
• Robbie Avila ranks 604th in the country with a team-high 12.6 points per game.
• Duquesne outscores opponents by 4.5 points per game (posting 80.1 points per game, 87th in college basketball, and allowing 75.6 per outing, 231st in college basketball) and has a +127 scoring differential.
• Tarence Guinyard leads Duquesne, averaging 16.5 points per game (179th in college basketball).
• The Billikens prevail in the rebound battle by an average of 9.1 boards. They are recording 38.3 rebounds per game (fifth in college basketball) compared to their opponents' 29.2 per outing.
• Dion Brown's 5.8 rebounds per game lead the Billikens and rank 330th in college basketball action.
• The 32.3 rebounds per game the Dukes accumulate rank 164th in the country. Their opponents record 31.4.
• Jakub Necas tops the Dukes with 5.2 rebounds per game (515th in college basketball).
• Saint Louis averages 109.1 points per 100 possessions on offense (10th in college basketball), and gives up 83.8 points per 100 possessions (seventh in college basketball).
• The Dukes rank 125th in college basketball with 99.8 points scored per 100 possessions, and 154th defensively with 94.2 points conceded per 100 possessions.

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