Reds vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 6:11 p.m.

The Tuesday slate in MLB includes a matchup between the Cincinnati Reds and the Miami Marlins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Reds vs Marlins Game Info

• Cincinnati Reds (11-12) vs. Miami Marlins (10-12)
• Date: Tuesday, April 22, 2025
• Time: 6:40 p.m. ET
• Venue: loanDepot park -- Miami, Florida
• Coverage: FDSFL and FDSOH

Reds vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-118) | MIA: (-100)
• Spread: CIN: -1.5 (+134) | MIA: +1.5 (-162)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Reds vs Marlins Probable Starting Pitchers

Probable Pitchers: Nick Martínez (Reds) - 0-3, 6.00 ERA vs Edward Brany Cabrera (Marlins) - 0-1, 6.52 ERA

The probable pitchers are Nick Martinez (0-3) for the Reds and Edward Brany Cabrera (0-1) for the Marlins. When Martinez starts, his team is 1-3-0 against the spread this season. This will be Martinez's first game as the moneyline favorite this season. Cabrera has started two games with set spreads, and the Marlins failed to cover in both opportunities. The Marlins were named the moneyline underdog for two Cabrera starts this season -- they lost both.

Reds vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (56.7%)

Reds vs Marlins Moneyline

• The moneyline numbers for Reds vs. Marlins reveal Cincinnati as the favorite (-118) and Miami as the underdog (-100) despite being the home team.

Reds vs Marlins Spread

• The Reds are at the Marlins and are favored by 1.5 runs (+134 to cover) on the runline. Miami is -162 to cover.

Reds vs Marlins Over/Under

• A total of 8.5 runs has been set for the Reds-Marlins game on April 22, with the over available at -118 and the under at -104.

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Reds vs Marlins Betting Trends

• The Reds have won in four of the seven contests they have been named as odds-on favorites in this year.
• Cincinnati has a record of 4-3 in contests when bookmakers favor them by -118 or more on the moneyline.
• Contests with the Reds have gone over the total set by bookmakers in 12 of 23 chances this season.
• The Reds are 13-10-0 against the spread in their 23 games with a line set by sportsbooks this season.
• The Marlins have been the moneyline underdog 20 total times this season. They've finished 8-12 in those games.
• Miami has gone 7-11 in games it has played as a moneyline underdog with odds of -100 or longer (38.9%).
• The Marlins have played in 22 games with a set over/under, and have combined with their opponents to go over the total 15 times (15-7-0).
• The Marlins have a 12-10-0 record against the spread this season (covering 54.5% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 22 hits, batting .242 this season with eight extra-base hits. He has an on-base percentage of .310 and a slugging percentage of .440.
• He is 87th in batting average, 102nd in on-base percentage, and 65th in slugging among qualifying batters in MLB.
• De La Cruz has hit safely in six straight games. In his last 10 outings he is hitting .231 with three home runs, six walks and 10 RBI.
• TJ Friedl leads Cincinnati in slugging percentage (.388) thanks to five extra-base hits. He's batting .294 with an on-base percentage of .358.
• Among all qualifying players, he ranks 38th in batting average, 51st in on-base percentage and 98th in slugging percentage.
• Friedl takes a five-game streak with at least one hit into this contest. In his last five games he is batting .455 with a double, a triple, three walks and four RBI.
• Gavin Lux leads Cincinnati in OBP (.419) this season, fueled by 23 hits.
• Lux enters this matchup with seven games in a row with at least one hit. In his last 10 outings he is hitting .424 with two doubles, a home run, nine walks and eight RBI.
• Matt McLain has been key for Cincinnati with 11 hits, an OBP of .349 plus a slugging percentage of .462.
• McLain takes a two-game hitting streak into this game. During his last five outings he is hitting .222 with a home run, five walks and four RBI.

Marlins Player Leaders

• Otto Lopez is batting .235 with five doubles, two home runs and nine walks. He's slugging .370 with an on-base percentage of .311.
• He ranks 92nd in batting average, 99th in on-base percentage and 107th in slugging percentage among all qualified hitters in the big leagues.
• Xavier Edwards' .319 slugging percentage leads his team. He has a batting average of .286 with an on-base percentage of .371.
• He is currently 44th in batting average, 40th in on-base percentage and 136th in slugging percentage among all qualified hitters.
• Eric Wagaman leads the Marlins with 18 hits.
• Kyle Stowers leads his team with a .388 OBP.

Reds vs Marlins Head to Head

• 4/21/2025: 6-3 MIA (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/8/2024: 10-4 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/7/2024: 6-4 MIA (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/6/2024: 8-2 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/5/2024: 10-3 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/14/2024: 3-2 MIA (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 7/13/2024: 10-6 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/12/2024: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/8/2023: 3-2 MIA (Favorite: Marlins, Spread: -1.5, Total: 10, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/7/2023: 5-2 CIN (Favorite: Marlins, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)

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