Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 1:12 p.m.

On Monday in MLB, the St. Louis Cardinals are up against the Cincinnati Reds.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Reds Game Info

• St. Louis Cardinals (63-61) vs. Cincinnati Reds (59-64)
• Date: Monday, August 17, 2026
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Cardinals.TV

Cardinals vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | CIN: (+106)
• Spread: STL: -1.5 (+132) | CIN: +1.5 (-160)
• Total: 9 -- Over: (-115) | Under: (-105)

Cardinals vs Reds Probable Starting Pitchers

Probable Pitchers: Quinn Mathews (Cardinals) - 0-1, 3.60 ERA vs Kent Emanuel (Reds) - 0-0, 0.00 ERA

The Cardinals will give the ball to Quinn Mathews (0-1, 3.60 ERA), who is eyeing win No. 1 on the season, and the Reds will counter with Kent Emanuel. Mathews and his team failed to cover the spread in his only opportunity this season as a starter. This will be Mathews' first start this season with his team as the moneyline favorite. Emanuel did not pitch as a moneyline underdog a season ago.

Cardinals vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.8%)

Cardinals vs Reds Moneyline

• The moneyline numbers for Cardinals vs. Reds reveal St. Louis as the favorite (-116) and Cincinnati as the underdog (+106) despite being the home team.

Cardinals vs Reds Spread

• The Reds are +1.5 on the run line against the Cardinals. The Reds are -160 to cover, and the Cardinals are +132.

Cardinals vs Reds Over/Under

• The over/under for the Cardinals versus Reds game on Aug. 17 has been set at 9, with -115 odds on the over and -105 odds on the under.

Bet on St. Louis Cardinals vs. Cincinnati Reds on FanDuel today!

Cardinals vs Reds Betting Trends

• The Cardinals have been victorious in 20, or 55.6%, of the 36 contests they have been chosen as favorites in this season.
• This season St. Louis has been victorious 15 times in 27 chances when named as a favorite of at least -116 on the moneyline.
• Contests with the Cardinals have gone over the total set by bookmakers in 48 of 120 chances this season.
• The Cardinals are 65-55-0 against the spread in their 120 games that had a posted line this season.
• The Reds have won 38 of the 79 games they were the underdog on the moneyline this season (48.1%).
• Cincinnati has a 24-33 record (winning 42.1% of its games) when playing as a moneyline underdog of +106 or longer.
• The Reds have combined with opponents to hit the over on the total 63 times this season for a 63-55-2 record against the over/under.
• The Reds have covered 52.5% of their games this season, going 63-57-0 against the spread.

Cardinals Player Leaders

• Alec Burleson leads St. Louis in slugging percentage (.494) thanks to 53 extra-base hits. He has a .288 batting average and an on-base percentage of .355.
• Among qualified hitters, he is 14th in batting average, his on-base percentage ranks 39th, and he is 19th in slugging.
• Burleson will look for his third straight game with a hit in this matchup. During his last five outings he is batting .389 with two doubles, two home runs, a walk and nine RBIs.
• Jordan Walker has 132 hits, which ranks first among St. Louis batters this season. He's batting .284 with 50 extra-base hits. He's also slugging .495 with an on-base percentage of .344.
• He is 19th in batting average, 50th in on-base percentage and 17th in slugging in the majors.
• JJ Wetherholt has collected 111 base hits, an OBP of .350 and a slugging percentage of .376 this season.
• Ivan Herrera leads St. Louis in OBP (.361) this season, fueled by 115 hits.

Reds Player Leaders

• Sal Stewart has a team-high .474 slugging percentage. He's batting .259 with an on-base percentage of .335.
• Including all qualifying players, he ranks 67th in batting average, while his on-base percentage is 67th and he is 32nd in slugging.
• Elly De La Cruz's 107 hits and .344 on-base percentage both lead his team. He has a batting average of .262 while slugging .477.
• He is currently 61st in batting average, 50th in on-base percentage and 31st in slugging percentage among all qualified hitters.
• JJ Bleday has 13 doubles, a triple, 20 home runs and 57 walks while batting .217.
• Tyler Stephenson is batting .251 with 16 doubles, 12 home runs and 36 walks.

Cardinals vs Reds Head to Head

• 7/26/2026: 5-3 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/25/2026: 7-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/24/2026: 4-2 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/7/2026: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/6/2026: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/5/2026: 10-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2026: 7-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2026: 8-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/17/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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