Purdue vs Northwestern College Basketball Prediction, Odds, Picks, Best Bets for March 4

The Northwestern Wildcats (13-16, 5-13 Big Ten) will attempt to build on a three-game win streak when they host the Purdue Boilermakers (22-7, 12-6 Big Ten) on March 4, 2026 at Welsh-Ryan Arena.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Purdue vs. Northwestern Game Info and Odds

• Game day: Wednesday, March 4, 2026
• Game time: 8:30 p.m. ET
• TV channel: Big Ten Network
• Location: Evanston, Illinois
• Arena: Welsh-Ryan Arena

Purdue vs. Northwestern Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Purdue win (72%)

Check out these betting trends and insights before you bet on Wednesday's Purdue-Northwestern spread (Purdue -10.5) or over/under (146.5 points).

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Purdue vs. Northwestern: ATS Betting Stats and Trends

• Purdue has won 13 games against the spread this season, while failing to cover 16 times.
• Northwestern has won 11 games against the spread this season, while failing to cover 18 times.
• Purdue (7-8) covers a lower percentage of games when it is favored by 10.5 points or more this season (46.7%) than Northwestern (3-2) does as a 10.5+-point underdog (60%).
• The Boilermakers have covered the spread in a lower percentage of their home games than away games. They have covered five times in 16 games at home, and they've covered six times in 10 games on the road.
• The Wildcats have been better against the spread away (5-5-0) than at home (5-10-0) this season.
• Purdue's record against the spread in conference games is 7-11-0.
• Northwestern has beaten the spread seven times in 18 Big Ten games.

Purdue vs. Northwestern: Moneyline Betting Stats

• Purdue has been the moneyline favorite in 23 games this season and has come away with the win 17 times (73.9%) in those contests.
• The Boilermakers have yet to lose in 12 games when named as moneyline favorite of -649 or better.
• Northwestern has won two of the 13 games it was listed as the moneyline underdog this season (15.4%).
• The Wildcats have played five times as a moneyline underdog with odds of +450 or longer, and lost each game.
• The moneyline set for this matchup implies Purdue has a 86.6% chance of coming away with a victory in the contest.

Purdue vs. Northwestern Head-to-Head Comparison

• Purdue averages 82.3 points per game (53rd in college basketball) while giving up 69.9 per contest (72nd in college basketball). It has a +359 scoring differential overall and outscores opponents by 12.4 points per game.
• Purdue's leading scorer, Braden Smith, is 291st in college basketball putting up 15.0 points per game.
• Northwestern has a +35 scoring differential, topping opponents by 1.2 points per game. It is putting up 73.7 points per game, 242nd in college basketball, and is allowing 72.5 per outing to rank 138th in college basketball.
• Nick Martinelli is seventh in college basketball with a team-high 22.5 points per game.
• The Boilermakers rank 97th in the nation at 33.5 rebounds per game. That's 6.5 more than the 27.0 their opponents average.
• Trey Kaufman-Renn tops the team with 8.9 rebounds per game (38th in college basketball action).
• The Wildcats grab 28.0 rebounds per game (342nd in college basketball) while conceding 32.1 per contest to opponents. They are outrebounded by 4.1 boards per game.
• Martinelli paces the team with 6.3 rebounds per game (239th in college basketball).
• Purdue puts up 110.0 points per 100 possessions (fourth in college basketball), while allowing 93.4 points per 100 possessions (134th in college basketball).
• The Wildcats score 98.1 points per 100 possessions (168th in college basketball), while allowing 96.5 points per 100 possessions (225th in college basketball).

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