Pittsburgh vs Syracuse Prediction, Odds, Picks, Best Bets for Week 8 2025

Saturday's slate in college football includes a matchup between the Pittsburgh Panthers and the Syracuse Orange.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Pittsburgh vs Syracuse Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Pittsburgh: (-360) | Syracuse: (+290)
• Spread: Pittsburgh: -9.5 (-115) | Syracuse: +9.5 (-105)
• Total: 54.5 -- Over: (-115) | Under: (-105)

Pittsburgh vs Syracuse Betting Trends

• Pittsburgh has four wins in six games against the spread this season.
• Pittsburgh has yet to lose ATS (2-0) as a 9.5-point favorite or greater this year.
• This season, five of Pittsburgh's six games have hit the over.
• Syracuse's record against the spread in 2025 is 3-3-0.
• Syracuse has won twice ATS (2-1) as a 9.5-point underdog or more this year.
• Of six Syracuse games so far this year, three have gone over the total.

Pittsburgh vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Panthers win (66.2%)

Pittsburgh vs Syracuse Point Spread

Pittsburgh is favored by 9.5 points against Syracuse. Pittsburgh is -115 to cover the spread, while Syracuse is -105.

Pittsburgh vs Syracuse Over/Under

Pittsburgh versus Syracuse on Oct. 18 has an over/under of 54.5 points, with the over -115 and the under -105.

Pittsburgh vs Syracuse Moneyline

Pittsburgh is a -360 favorite on the moneyline, while Syracuse is a +290 underdog.

Pittsburgh vs. Syracuse Points Insights

Pittsburgh vs. Syracuse Game Info

• Game day: Saturday, October 18, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Syracuse, New York
• Stadium: JMA Wireless Dome

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Pittsburgh vs. Syracuse analysis on FanDuel Research.