Penn State vs UCLA Prediction, Odds, Picks, Best Bets for Week 6 2025

The Saturday slate in college football includes a matchup between the Penn State Nittany Lions and the UCLA Bruins.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Penn State vs UCLA Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Penn State: (-4000) | UCLA: (+1400)
• Spread: Penn State: -24.5 (-115) | UCLA: +24.5 (-105)
• Total: 50.5 -- Over: (-106) | Under: (-114)

Penn State vs UCLA Betting Trends

• Penn State is winless against the spread this season.
• Penn State has no wins ATS (0-3) as a 24.5-point favorite or greater this season.
• Penn State has played four games this year, and three of them have hit the over.
• UCLA has but one win versus the spread this season.
• One UCLA game (out of four) has gone over the point total this season.

Penn State vs UCLA Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (90.5%)

Penn State vs UCLA Point Spread

UCLA is the underdog by 24.5 points against Penn State. UCLA is -115 to cover the spread, and Penn State is -105.

Penn State vs UCLA Over/Under

A combined point total of 50.5 has been set for Penn State-UCLA on Oct. 4, with the over at -106 and the under at -114.

Penn State vs UCLA Moneyline

Looking at the moneyline for UCLA-Penn State, UCLA is the underdog at +1400, and Penn State is -4000.

Penn State vs. UCLA Points Insights

Penn State vs. UCLA Game Info

• Game day: Saturday, October 4, 2025
• Game time: 3:30 p.m. ET
• TV channel: CBS
• Location: Pasadena, California
• Stadium: Rose Bowl

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Check out even more in-depth Penn State vs. UCLA analysis on FanDuel Research.