Penn State vs Northwestern Prediction, Odds, Picks, Best Bets for Week 7 2025

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NCAA football action on Saturday includes the Penn State Nittany Lions taking on the Northwestern Wildcats.

We've got you covered, in terms of the vital information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Penn State vs Northwestern Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Penn State: (-2000) | Northwestern: (+1040)
Spread: Penn State: -21.5 (-105) | Northwestern: +21.5 (-115)
Total: 47.5 -- Over: (-110) | Under: (-110)

Penn State hasn't won a game against the spread this season.
Penn State has yet to win ATS (0-4) when playing as at least 21.5-point favorites this year.
This year, four of Penn State's five games have hit the over.
Northwestern has three wins in five contests against the spread this season.
Northwestern has covered every time (1-0) as a 21.5-point or greater underdog this year.
Northwestern has had one game (of five) go over the total this year.

All college football win probability predictions and picks are according to numberFire.
Prediction: Nittany Lions win (89.8%)

Northwestern is the underdog by 21.5 points against Penn State. Northwestern is -105 to cover the spread, and Penn State is -115.

An over/under of 47.5 has been set for Penn State-Northwestern on Oct. 11, with the over being -110 and the under -110.

Penn State is the favorite, -2000 on the moneyline, while Northwestern is a +1040 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Penn State	38.6	30	17.8	27	53.1	5
Northwestern	23.6	103	17.0	23	46.3	5

Check out even more in-depth Penn State vs. Northwestern analysis on FanDuel Research.

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