Panthers vs Sabres NHL Prediction, Odds, Picks, Best Bets for Oct. 18

On Saturday in the NHL, the Florida Panthers are up against the Buffalo Sabres.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NHL moneyline insights you need to know.

Panthers vs Sabres Game Info

• Florida Panthers (3-3) vs. Buffalo Sabres (1-3)
• Date: Saturday, October 18, 2025
• Time: 1 p.m. ET
• Venue: KeyBank Center -- Buffalo, New York
• Coverage: ESPN+

Panthers vs Sabres Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Sabres Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (54.8%)

Panthers vs Sabres Puck Line

• The Panthers are favored by 1.5 goals. The Panthers are +180 to cover the spread, with the Sabres being -225.

Panthers vs Sabres Over/Under

• An over/under of 5.5 has been set for Panthers-Sabres on Oct. 18, with the over being -138 and the under +112.

Panthers vs Sabres Moneyline

• Florida is a -140 favorite on the moneyline, while Buffalo is a +116 underdog at home.

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