Panthers vs Bruins NHL Prediction, Odds, Picks, Best Bets for Oct. 21

The Florida Panthers are among the NHL squads busy on Tuesday, up against the Boston Bruins.

Get the latest NHL odds ahead of this game on FanDuel Sportsbook.

Panthers vs Bruins Game Info

• Florida Panthers (3-4) vs. Boston Bruins (3-4)
• Date: Tuesday, October 21, 2025
• Time: 7:30 p.m. ET
• Venue: TD Garden -- Boston, Massachusetts
• Coverage: ESPN

Panthers vs Bruins Odds

All NHL odds, betting lines and prop bets are available on FanDuel Sportsbook.

Panthers vs Bruins Prediction & Pick

All NHL win probability predictions and picks are according to numberFire.

• Prediction: Panthers win (65.2%)

Panthers vs Bruins Puck Line

• The Panthers are favored by 1.5 goals against the Bruins. The Panthers are +158 to cover the spread, while the Bruins are -196.

Panthers vs Bruins Over/Under

• A total of 5.5 goals has been set for the Panthers-Bruins matchup on Oct. 21, with the over available at -115 and the under at -105.

Panthers vs Bruins Moneyline

• The moneyline numbers for Panthers vs. Bruins reveal Florida as the favorite (-152) and Boston as the underdog (+126) despite being the home team.

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