Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 3

Odds updated as of 10:11 a.m.

The San Diego Padres will face the Pittsburgh Pirates in MLB action on Saturday.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Pirates Game Info

• San Diego Padres (20-11) vs. Pittsburgh Pirates (12-21)
• Date: Saturday, May 3, 2025
• Time: 4:05 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and SDPA

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-110) | PIT: (-106)
• Spread: SD: -1.5 (+142) | PIT: +1.5 (-172)
• Total: 9 -- Over: (-118) | Under: (-104)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 1-3, 4.28 ERA vs Bailey Falter (Pirates) - 1-3, 5.93 ERA

The Padres will give the nod to Randy Vasquez (1-3, 4.28 ERA), who is eyeing win No. 2 on the season, and the Pirates will counter with Bailey Falter (1-3, 5.93 ERA). Vasquez's team is 3-3-0 against the spread in his starts this season. This will be Vasquez's first game as the moneyline favorite this season. The Pirates have a 2-4-0 record against the spread in Falter's starts. The Pirates have a 1-3 record in Falter's four starts this season when they were the underdog on the moneyline.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.9%)

Padres vs Pirates Moneyline

• San Diego is the favorite, -110 on the moneyline, while Pittsburgh is a -106 underdog despite being at home.

Padres vs Pirates Spread

• The Padres are at the Pirates and are favored by 1.5 runs on the spread. The Padres are +142 to cover the runline, with the Pirates being -172.

Padres vs Pirates Over/Under

• A combined run total of 9 has been set for Padres-Pirates on May 3, with the over at -118 and the under at -104.

Bet on San Diego Padres vs. Pittsburgh Pirates on FanDuel today!

Padres vs Pirates Betting Trends

• The Padres have been chosen as favorites in 16 games this year and have walked away with the win 12 times (75%) in those games.
• San Diego has a record of 12-4 in contests when oddsmakers favor them by -110 or more on the moneyline.
• The Padres and their opponents have gone over in 13 of their 31 games with a total set by sportsbooks this season.
• In 31 games with a line this season, the Padres have a mark of 18-13-0 against the spread.
• The Pirates have won 33.3% of the games this season they were the moneyline underdog (7-14).
• Pittsburgh has a 6-14 record (winning just 30% of its games) when it has played as a moneyline underdog of -106 or longer.
• The Pirates have had an over/under set by oddsmakers 33 times, and have combined with opponents to go over the total in 16 of those games (16-16-1).
• The Pirates have collected a 12-21-0 record ATS this season (covering only 36.4% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego in OBP (.419), slugging percentage (.602) and total hits (39) this season. He has a .345 batting average.
• Among all qualifying hitters in MLB, he is third in batting average, fifth in on-base percentage, and sixth in slugging.
• Manny Machado is batting .278 with 10 doubles, two home runs and 11 walks, while slugging .417 with an on-base percentage of .339.
• His batting average ranks 41st among qualified players, his on-base percentage 64th, and his slugging percentage 74th.
• Machado brings a three-game streak with at least one hit into this one. In his last five games he is hitting .263 with a double, a walk and three RBI.
• Luis Arraez has collected 31 base hits, an OBP of .346 and a slugging percentage of .465 this season.
• Arraez heads into this game with three games in a row with at least one hit. In his last five games he is hitting .429 with a double, a triple, two walks and five RBI.
• Xander Bogaerts has been key for San Diego with 26 hits, an OBP of .333 plus a slugging percentage of .346.

Pirates Player Leaders

• Oneil Cruz has 26 hits with a .364 on-base percentage, leading the Pirates in both statistics. He's batting .245 and slugging .519.
• Including all the qualifying hitters in MLB, his batting average is 85th, his on-base percentage ranks 38th, and he is 23rd in slugging.
• Andrew McCutchen has six doubles, three home runs and 12 walks while hitting .264. He's slugging .429 with an on-base percentage of .356.
• He is currently 65th in batting average, 47th in on-base percentage and 65th in slugging percentage among all qualified hitters.
• Bryan Reynolds has a team-high .377 slugging percentage.
• Enmanuel Valdez is batting .216 with three doubles, two triples, two home runs and 11 walks.

Padres vs Pirates Head to Head

• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/13/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/12/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/8/2024: 7-6 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/7/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/6/2024: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/26/2023: 3-2 PIT (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/25/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 7/24/2023: 8-4 PIT (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -275, Underdog Moneyline: +225)

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