Padres vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for May 27

Odds updated as of 2:12 p.m.

MLB action on Tuesday includes the San Diego Padres playing the Miami Marlins.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Marlins Game Info

• San Diego Padres (30-22) vs. Miami Marlins (21-31)
• Date: Tuesday, May 27, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSFL

Padres vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-162) | MIA: (+136)
• Spread: SD: -1.5 (+128) | MIA: +1.5 (-154)
• Total: 8 -- Over: (-100) | Under: (-122)

Padres vs Marlins Probable Starting Pitchers

Probable Pitchers: Stephen Kolek (Padres) - 2-1, 2.84 ERA vs Max Meyer (Marlins) - 3-4, 4.15 ERA

This contest's pitching matchup is set, as the Padres will send Stephen Kolek (2-1) to the mound, while Max Meyer (3-4) will take the ball for the Marlins. Kolek's team is 2-2-0 against the spread in his starts this season. Kolek's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. The Marlins have a 7-3-0 record against the spread in Meyer's starts. The Marlins are 3-4 in Meyer's seven starts this season that they were the moneyline underdog.

Padres vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (66.5%)

Padres vs Marlins Moneyline

• The moneyline numbers for Padres vs. Marlins reveal San Diego as the favorite (-162) and Miami as the underdog (+136) on the road.

Padres vs Marlins Spread

• The Padres are favored by 1.5 runs at home against the Marlins. The Padres are +128 to cover the spread, while the Marlins are -154.

Padres vs Marlins Over/Under

• A total of 8 runs has been set for the Padres-Marlins contest on May 27, with the over available at -100 and the under at -122.

Bet on San Diego Padres vs. Miami Marlins on FanDuel today!

Padres vs Marlins Betting Trends

• The Padres have come away with 17 wins in the 27 contests they have been listed as the favorites in this season.
• San Diego has a record of 10-4 when favored by -162 or more this year.
• The Padres and their opponents have gone over in 21 of their 51 games with a total set by sportsbooks this season.
• The Padres have posted a record of 27-24-0 against the spread this season.
• The Marlins have won 37% of the games this season they were the moneyline underdog (17-29).
• Miami has a 9-15 record (winning just 37.5% of its games) when playing as a moneyline underdog of +136 or longer.
• The Marlins have played in 52 games with a set over/under, and have combined with their opponents to go over the total 30 times (30-22-0).
• The Marlins are 29-23-0 ATS this season.

Padres Player Leaders

• Manny Machado leads San Diego with an OBP of .391, plus a team-best slugging percentage of .497. He's batting .319 on the season.
• He is eighth in batting average, 13th in on-base percentage, and 31st in slugging among all qualifying hitters in MLB.
• Machado has picked up at least one hit in four games in a row. In his last five games he is batting .368 with a double, three home runs, three walks and four RBIs.
• Fernando Tatis Jr. leads San Diego in total hits (55) this season while batting .275 with 20 extra-base hits. He's slugging .500 with an on-base percentage of .342.
• Among all qualified, he ranks 46th in batting average, 59th in on-base percentage and 27th in slugging percentage.
• Luis Arraez is batting .281 with a .405 slugging percentage and 16 RBI this year.
• Gavin Sheets leads San Diego in total hits (45) this season while batting .274 with 17 extra-base hits.

Marlins Player Leaders

• Kyle Stowers has a team-best OBP (.369) and slugging percentage (.528), while leading the Marlins in hits (54, while batting .300).
• Including all the qualified players in the majors, his batting average places him 14th, his on-base percentage ranks 32nd, and he is 19th in slugging.
• Eric Wagaman is batting .246 with 10 doubles, a triple, four home runs and 13 walks. He's slugging .380 with an on-base percentage of .295.
• Including all qualified players, he is 96th in batting average, 128th in on-base percentage and 113th in slugging percentage.
• Otto Lopez has five doubles, three home runs and 14 walks while batting .222.
• Agustin Ramirez is batting .241 with 11 doubles, six home runs and 10 walks.

Padres vs Marlins Head to Head

• 5/26/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/11/2024: 7-6 MIA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/10/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/9/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2024: 9-1 MIA (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/28/2024: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/27/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/23/2023: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/22/2023: 3-0 MIA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/21/2023: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)

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