Orioles vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 9

Odds updated as of 6:12 p.m.

Wednesday's slate in the MLB includes a matchup between the Cleveland Guardians and the Baltimore Orioles.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Orioles Game Info

• Cleveland Guardians (74-72) vs. Baltimore Orioles (70-76)
• Date: Wednesday, September 9, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and CleGuardians.TV

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | BAL: (-102)
• Spread: CLE: -1.5 (+146) | BAL: +1.5 (-178)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Foster Griffin (Guardians) - 15-4, 3.26 ERA vs Shane Baz (Orioles) - 5-15, 3.91 ERA

The probable pitchers are Foster Griffin (15-4) for the Guardians and Shane Baz (5-15) for the Orioles. Griffin's team is 17-9-0 against the spread this season in his starts. Griffin's team is 7-2 this season when he starts and they are the moneyline favorite. The Orioles have a 12-15-0 record against the spread in Baz's starts. The Orioles have been the moneyline underdog in 15 of Baz's starts this season, and they went 2-13 in those games.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (53.7%)

Guardians vs Orioles Moneyline

• Cleveland is the favorite, -116 on the moneyline, while Baltimore is a -102 underdog despite being at home.

Guardians vs Orioles Spread

• The Guardians are at the Orioles and are favored by 1.5 runs on the spread. The Guardians are +146 to cover the runline, with the Orioles being -178.

Guardians vs Orioles Over/Under

• A total of 8.5 runs has been set for the Guardians-Orioles game on Sept. 9, with the over available at -114 and the under at -106.

Bet on Cleveland Guardians vs. Baltimore Orioles on FanDuel today!

Guardians vs Orioles Betting Trends

• The Guardians have won in 42, or 51.2%, of the 82 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 40-36 when favored by -116 or more this year.
• The Guardians and their opponents have gone over in 67 of their 138 games with a total set by sportsbooks this season.
• In 138 games with a line this season, the Guardians have a mark of 65-73-0 against the spread.
• The Orioles have been the underdog on the moneyline 71 total times this season. They've finished 32-39 in those games.
• Baltimore is 26-33 (winning 44.1% of its games) when playing as a moneyline underdog of -102 or longer.
• The Orioles have played in 145 games with a set over/under, and have combined with their opponents to go over the total 73 times (73-68-4).
• The Orioles have a 74-71-0 record against the spread this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 131 hits, batting .294 this season with 44 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .458.
• Among qualified hitters in MLB, he ranks 10th in batting average, 23rd in on-base percentage, and 41st in slugging.
• Jose Ramirez is hitting .237 with 24 doubles, 11 home runs and 56 walks. He's slugging .374 with an on-base percentage of .328.
• He ranks 105th in batting average, 71st in on-base percentage and 117th in slugging in MLB.
• Ramirez takes a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .150 with .
• Steven Kwan leads the Guardians with an OPS of .707. He has a slash line of .273/.371/.335 this season.
• Kwan enters this game with three games in a row with at least one hit. In his last five games he is batting .300 with three doubles and two walks.
• Brayan Rocchio has 13 home runs, 62 RBI and a batting average of .249 this season.
• Rocchio has safely hit in three games in a row. In his last five games he is batting .313 with a double, a home run, a walk and three RBIs.

Orioles Player Leaders

• Pete Alonso has a team-best OBP (.361) and slugging percentage (.499), and leads the Orioles in hits (146, while batting .268).
• Including all qualified hitters, he ranks 43rd in batting average, while his on-base percentage ranks 27th and he is 14th in slugging.
• Gunnar Henderson is batting .219 with 25 doubles, five triples, 22 home runs and 61 walks. He's slugging .395 with an on-base percentage of .303.
• His batting average ranks 125th among all qualified players, his on-base percentage ranks 117th, and he is 94th in slugging.
• Coby Mayo is batting .223 with 14 doubles, three triples, 21 home runs and 28 walks.
• Leody Taveras is hitting .217 with 16 doubles, six triples, eight home runs and 40 walks.

Guardians vs Orioles Head to Head

• 9/8/2026: 9-5 CLE (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/7/2026: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/19/2026: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/18/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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