Orioles vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 9

Odds updated as of 1:12 a.m.

The Baltimore Orioles versus the Cleveland Guardians is on the MLB schedule for Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Orioles vs Guardians Game Info

• Baltimore Orioles (70-76) vs. Cleveland Guardians (74-72)
• Date: Wednesday, September 9, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and CleGuardians.TV

Orioles vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-112) | CLE: (-104)
• Spread: BAL: +1.5 (-172) | CLE: -1.5 (+142)
• Total: 8.5 -- Over: (-122) | Under: (+100)

Orioles vs Guardians Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 5-15, 3.91 ERA vs Foster Griffin (Guardians) - 15-4, 3.26 ERA

This contest's pitching matchup is set, as the Orioles will send Shane Baz (5-15) to the mound, while Foster Griffin (15-4) will get the nod for the Guardians. Baz and his team are 12-15-0 ATS this season when he starts. When Baz starts a game and his team is the favorite on the moneyline, they have a record of 5-6. When Griffin starts, the Guardians have gone 17-9-0 against the spread. The Guardians are 12-5 in Griffin's 17 starts this season that they were the underdog on the moneyline.

Orioles vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (54.8%)

Orioles vs Guardians Moneyline

• The moneyline numbers for Orioles vs. Guardians reveal Baltimore as the favorite (-112) and Cleveland as the underdog (-104) on the road.

Orioles vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Orioles. The Guardians are +142 to cover, while the Orioles are -172 to cover as a 1.5-run underdog on the runline.

Orioles vs Guardians Over/Under

• The over/under for the Orioles versus Guardians contest on Sept. 9 has been set at 8.5, with -122 odds on the over and +100 odds on the under.

Bet on Baltimore Orioles vs. Cleveland Guardians on FanDuel today!

Orioles vs Guardians Betting Trends

• The Orioles have won in 36, or 52.9%, of the 68 contests they have been named as odds-on favorites in this year.
• Baltimore has a record of 34-30 in contests when bookmakers favor them by -112 or more on the moneyline.
• The Orioles' games have gone over the total in 73 of their 145 opportunities.
• The Orioles have an against the spread mark of 74-71-0 in 145 games with a line this season.
• The Guardians have won 27 of the 54 games they were listed as the moneyline underdog this season (50%).
• Cleveland is 26-25 (winning 51% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Guardians have combined with opponents to go over the total 67 times this season for a 67-71-0 record against the over/under.
• The Guardians have put together a 65-73-0 record against the spread this season.

Orioles Player Leaders

• Pete Alonso leads Baltimore with 146 hits and an OBP of .361, plus a team-best slugging percentage of .499. He's batting .268.
• Among the qualified hitters in MLB, his batting average ranks 43rd, his on-base percentage ranks 27th, and he is 13th in slugging.
• Gunnar Henderson is hitting .219 with 25 doubles, five triples, 22 home runs and 61 walks. He's slugging .395 with an on-base percentage of .303.
• Among qualifying hitters, he is 125th in batting average, 117th in on-base percentage and 94th in slugging percentage.
• Coby Mayo has 79 hits this season and has a slash line of .223/.288/.456.
• Leody Taveras has eight home runs, 53 RBI and a batting average of .217 this season.

Guardians Player Leaders

• Chase DeLauter paces the Guardians with 131 hits. He's batting .294 and slugging .458 with an on-base percentage of .365.
• He ranks 10th in batting average, 23rd in on-base percentage and 41st in slugging percentage among all qualifying hitters in MLB.
• Jose Ramirez has 24 doubles, 11 home runs and 56 walks while batting .237. He's slugging .374 with an on-base percentage of .328.
• His batting average is 107th among all qualified players, his on-base percentage ranks 72nd, and he is 117th in slugging.
• Steven Kwan has a .371 on-base percentage and a .335 slugging percentage, both team-best numbers for the Guardians.
• Brayan Rocchio is batting .249 with 20 doubles, two triples, 13 home runs and 33 walks.

Orioles vs Guardians Head to Head

• 9/8/2026: 9-5 CLE (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/7/2026: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/19/2026: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/18/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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